143603-14-9Relevant academic research and scientific papers
Catalytic Asymmetric Synthesis of Optically Active Secondary Alcohols Deuterated on the Secondary Carbon by the Enantioselective Alkylation of Aldehydes
Soai, Kenso,Hirose, Yuji,Sakata, Shuichi
, p. 1734 - 1735 (1992)
Optically active secondary alcohols deuterated on the secondary carbon were obtained in high enantiomeric excesses from the enantioselective addition of dialkylzincs to aldehyde-formyl-d's using chiral catalysts.
Enantioselective reduction of aromatic and aliphatic ketones catalyzed by ruthenium complexes attached to β-cyclodextrin
Schlatter, Alain,Kundu, Mrinal K.,Woggon, Wolf-D.
, p. 6731 - 6734 (2007/10/03)
Water-soluble chiral Ru complexes with a β-cyclodextrin unit have been shown to catalyze the reduction of aliphatic ketones (see scheme) with up to 97% ee and in good to excellent yields in the presence of sodium formate. The β-cyclodextrin unit is an essential component of the catalyst. It contributes to the unprecedented levels of enantioselectivity observed through the preorganization of the substrates in the hydrophobic cavity.
