1436416-04-4

Basic information

• Product Name: N-[3-formyl-6-((R)-3-phenylmorpholin-4-yl)-pyridin-2-yl]-2,2-dimethylpropionamide
• Synonyms: N-[3-formyl-6-((R)-3-phenylmorpholin-4-yl)-pyridin-2-yl]-2,2-dimethylpropionamide
• CAS NO: 1436416-04-4
• Molecular Weight: 367.448
• Mol File: 1436416-04-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: N-[3-formyl-6-((R)-3-phenylmorpholin-4-yl)-pyridin-2-yl]-2,2-dimethylpropionamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-[3-formyl-6-((R)-3-phenylmorpholin-4-yl)-pyridin-2-yl]-2,2-dimethylpropionamide(1436416-04-4)
• EPA Substance Registry System: N-[3-formyl-6-((R)-3-phenylmorpholin-4-yl)-pyridin-2-yl]-2,2-dimethylpropionamide(1436416-04-4)

Safety Data

• Hazardous Substances Data: 1436416-04-4(Hazardous Substances Data)

Upstream product

• 127446-34-8 N-(6-chloro-3-formylpyridin-2-yl)-2,2-dimethylpropionamide 
• 138713-44-7 3-(-)-Phenyl morpholine 
• 86847-84-9 2,2-Dimethyl-N-(6-chloro-2-pyridinyl)propanamide 

Downstream Products

• 1436416-05-5 N-[3-hydroxy-6-((R)-3-phenylmorpholin-4-yl)-pyridin-2-yl]-2,2-dimethylpropionamide 
• 1436416-06-6 C₁₆H₁₇N₃O₂ 
• 138713-44-7 3-(-)-Phenyl morpholine 

Relevant articles and documents

Synthesis of a cis 2,5-disubstituted morpholine by de-epimerization: Application to the multigram scale synthesis of a mineralocorticoid antagonist

A convergent route to multigram quantities of a mineralocorticoid antagonist 3 is described. Starting from (R)-phenylglycinol, the synthesis of cis 2,5-morpholine 2 is accomplished utilizing a de-epimerization to install the second stereogenic center. The multigram synthesis of 3 was completed through a sequence of an SNAr reaction, Dakin oxidation, alkylation, and cyclization to provide a crystalline solid.