N-[3-formyl-6-((R)-3-phenylmorpholin-4-yl)-pyridin-2-yl]-2,2-dimethylpropionamide

Base Information

Chemical Name:N-[3-formyl-6-((R)-3-phenylmorpholin-4-yl)-pyridin-2-yl]-2,2-dimethylpropionamide
CAS No.:1436416-04-4
Molecular Formula:C₂₁H₂₅N₃O₃
Molecular Weight:367.448
Hs Code.:

Synonyms:N-[3-formyl-6-((R)-3-phenylmorpholin-4-yl)-pyridin-2-yl]-2,2-dimethylpropionamide

Suppliers and Price of N-[3-formyl-6-((R)-3-phenylmorpholin-4-yl)-pyridin-2-yl]-2,2-dimethylpropionamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 1 raw suppliers

Chemical Property of N-[3-formyl-6-((R)-3-phenylmorpholin-4-yl)-pyridin-2-yl]-2,2-dimethylpropionamide

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of N-[3-formyl-6-((R)-3-phenylmorpholin-4-yl)-pyridin-2-yl]-2,2-dimethylpropionamide

There total 2 articles about N-[3-formyl-6-((R)-3-phenylmorpholin-4-yl)-pyridin-2-yl]-2,2-dimethylpropionamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 127446-34-8
N-(6-chloro-3-formylpyridin-2-yl)-2,2-dimethylpropionamide

: 138713-44-7,74572-03-5
3-(-)-Phenyl morpholine

: 1436416-04-4
N-[3-formyl-6-((R)-3-phenylmorpholin-4-yl)-pyridin-2-yl]-2,2-dimethylpropionamide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 100 ℃; for 18h;
DOI:10.1021/op400101p

Reference yield:

: 86847-84-9
2,2-Dimethyl-N-(6-chloro-2-pyridinyl)propanamide

: 1436416-04-4
N-[3-formyl-6-((R)-3-phenylmorpholin-4-yl)-pyridin-2-yl]-2,2-dimethylpropionamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: n-butyllithium; N,N,N,N,-tetramethylethylenediamine / 2-methyltetrahydrofuran / 1 h / -40 - -25 °C / Inert atmosphere

1.2: 1.5 h / -15 - 15 °C / Inert atmosphere

2.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 18 h / 100 °C

With n-butyllithium; N,N,N,N,-tetramethylethylenediamine; N-ethyl-N,N-diisopropylamine; In 2-methyltetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1021/op400101p

Reference yield: 52.0%

: 1436416-04-4
N-[3-formyl-6-((R)-3-phenylmorpholin-4-yl)-pyridin-2-yl]-2,2-dimethylpropionamide

: 1436416-05-5
N-[3-hydroxy-6-((R)-3-phenylmorpholin-4-yl)-pyridin-2-yl]-2,2-dimethylpropionamide

: 1436416-06-6
C₁₆H₁₇N₃O₂

: 138713-44-7,74572-03-5
3-(-)-Phenyl morpholine

Guidance literature:: With urea hydrogen peroxide adduct; sodium hydroxide; In methanol; at 0 ℃; for 42h; Reagent/catalyst; Solvent; Concentration;
DOI:10.1021/op400101p