86847-84-9

Basic information

• Product Name: N-(6-CHLORO-PYRIDIN-2-YL)-2,2-DIMETHYL-PROPIONAMIDE
• Synonyms: N-(6-CHLORO-PYRIDIN-2-YL)-2,2-DIMETHYL-PROPIONAMIDE;N-(6-chloropyridin-2-yl)pivalamide;N-(6-chloropyridin-2-yl)-2,2-dimethylpropanamide
• CAS NO: 86847-84-9
• Molecular Formula: C₁₀H₁₃ClN₂O
• Molecular Weight: 212.68
• EINECS: 604-604-1
• Mol File: 86847-84-9.mol
• Article Data: 17

Chemical Properties

• Melting Point: 86-87 °C(Solv: ethyl acetate (141-78-6); hexane (110-54-3))
• Boiling Point: 375.384 °C at 760 mmHg
• Flash Point: 180.826 °C
• Appearance: /
• Density: 1.2 g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.561
• Storage Temp.: Inert atmosphere,Room Temperature
• PKA: 13.15±0.70(Predicted)
• CAS DataBase Reference: N-(6-CHLORO-PYRIDIN-2-YL)-2,2-DIMETHYL-PROPIONAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: N-(6-CHLORO-PYRIDIN-2-YL)-2,2-DIMETHYL-PROPIONAMIDE(86847-84-9)
• EPA Substance Registry System: N-(6-CHLORO-PYRIDIN-2-YL)-2,2-DIMETHYL-PROPIONAMIDE(86847-84-9)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 22
• HazardClass: IRRITANT
• Hazardous Substances Data: 86847-84-9(Hazardous Substances Data)

Usage

General Description

"N-(6-chloro-pyridin-2-yl)-2,2-dimethyl-propionamide" is a chemical compound that belongs to the class of pyridine derivatives. Its molecular formula is C12H15ClN2O, and it has a molecular weight of 236.71 g/mol. N-(6-CHLORO-PYRIDIN-2-YL)-2,2-DIMETHYL-PROPIONAMIDE is commonly used in the pharmaceutical industry for the synthesis of various drugs due to its ability to act as a building block for creating new chemical entities. It is also known for its potential biological activities, making it a valuable tool in drug discovery and development. Additionally, it is used in research and development laboratories for various experimental purposes.

InChI:InChI=1/C10H13ClN2O/c1-10(2,3)9(14)13-8-6-4-5-7(11)12-8/h4-6H,1-3H3,(H,12,13,14)

Upstream product

• 45644-21-1 6-chloropyridin-2-amine 
• 3282-30-2 pivaloyl chloride 

Downstream Products

• 127446-34-8 N-(6-chloro-3-formylpyridin-2-yl)-2,2-dimethylpropionamide 
• 915140-96-4 6-Chloro-1H-pyrrolo[2,3-b]pyridine-3-carboxylic acid 
• 1296201-71-2 C₁₅H₂₁ClN₂OSi 
• 97941-89-4 5,6-dichloropyridine-2,3-diamine 
• 1075234-64-8 (1R)-1-({4-[(2,3-dihydro[1,4]oxathiino[2,3-c]pyridin-7-ylmethyl)amino]-1-piperidinyl}methyl)-1,2-dihydro-4H,9H-imidazo[1,2,3-ij]-1,8-naphthyridine-4,9-dione benzoate 
• 1075234-57-9 (1R)-1-({4-[([1,3]oxathiolo[5,4-c]pyridin-6-ylmethyl)amino]-1-piperidinyl}methyl)-1,2-dihydro-4H,9H-imidazo[1,2,3-ij]-1,8-naphthyridine-4,9-dione benzoate 
• 1031284-87-3 5-{8-[4-(4-isopropylpiperazin-1-yl)phenylamino]imidazo[1,2-a]pyridin-5-yl}-2,3-dihydro-isoindol-1-one 
• 1031290-25-1 (5-chloroimidazo[1,2-a]pyridin-8-yl)-[4-(4-isopropylpiperazin-1-yl)phenyl]amine 
• 1031289-77-6 5-chloro-8-iodo-imidazo[1,2-a]pyridine 

Relevant articles and documents

Methods for treating neisseria gonorrhoeae infection with substituted 1,2-dihydro-2A,5,8A-triazaacenaphthylene-3,8-diones

The present invention relates to methods for treating Neisseria Gonorrhoeae infection which comprises administering to a subject in need thereof novel 1,2-dihydro-2a,5,8a-triazaacenaphthylene-3,8-dione compounds: or pharmaceutically acceptable salts thereof and/or corresponding pharmaceutical compositions.

Synthesis of new imidazopyridine nucleoside derivatives designed as maribavir analogues

The strong inhibition of Human Cytomegalovirus (HCMV) replication by benzimidazole nucleosides, like Triciribine and Maribavir, has prompted us to expand the structure-activity relationships of the benzimidazole series, using as a central core the imidazo[4,5-b]pyridine scafflold. We have thus synthesized a number of novel amino substituted imidazopyridine nucleoside derivatives, which can be considered as 4-(or 7)-aza-d-isosters of Maribavir and have evaluated their potential antiviral activity. The target compounds were synthesized upon glycosylation of suitably substituted 2-aminoimidazopyridines, which were prepared in six steps starting from 2-amino-6-chloropyridine. Even if the new compounds possessed only a slight structural modification when compared to the original drug, they were not endowed with interesting antiviral activity. Even so, three derivatives showed promising cytotoxic potential.

TYK2 INHIBITORS AND USES THEREOF

The present invention provides compounds, compositions thereof, and methods of using the same for the inhibition of TYK2, and the treatment of TYK2-mediated disorders.