143659-19-2

Basic information

• Product Name: 5-(4-METHYLPHENYL)-1,3-OXAZOLE
• Synonyms: 5-(4-METHYLPHENYL)-1,3-OXAZOLE;5-(4-METHYLPHENYL)OXAZOLE;4-(1,3-Oxazol-5-yl)toluene;5-(p-Tolyl)oxazole
• CAS NO: 143659-19-2
• Molecular Formula: C₁₀H₉NO
• Molecular Weight: 159.18
• Mol File: 143659-19-2.mol
• Article Data: 15

Chemical Properties

• Melting Point: 65-67
• Boiling Point: 273.9 °C at 760 mmHg
• Flash Point: 108.6 °C
• Appearance: /
• Density: 1.082 g/cm³
• Vapor Pressure: 0.00936mmHg at 25°C
• Refractive Index: 1.539
• CAS DataBase Reference: 5-(4-METHYLPHENYL)-1,3-OXAZOLE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(4-METHYLPHENYL)-1,3-OXAZOLE(143659-19-2)
• EPA Substance Registry System: 5-(4-METHYLPHENYL)-1,3-OXAZOLE(143659-19-2)

Safety Data

• Hazard Codes: Xi
• Hazardous Substances Data: 143659-19-2(Hazardous Substances Data)

Usage

General Description

5-(4-Methylphenyl)-1,3-oxazole is a chemical compound with a molecular formula C10H9NO. It belongs to the class of organic compounds known as benzene and substituted derivatives, and it contains an oxazole ring with a 4-methylphenyl group attached at position 5. 5-(4-METHYLPHENYL)-1,3-OXAZOLE is commonly used as a building block in the synthesis of various pharmaceuticals and agrochemicals. It may also have potential applications in the field of materials science and as a reagent in organic chemistry research. Its chemical structure and properties make it a valuable addition to the field of organic synthesis and drug discovery.

InChI:InChI=1/C10H9NO/c1-8-2-4-9(5-3-8)10-6-11-7-12-10/h2-7H,1H3

Upstream product

• 38622-91-2 [(p-methylphenyl)sulfonylmethyl]isonitrile 
• 104-81-4 4-Methylbenzyl bromide 
• 589-18-4 4-Methylbenzyl alcohol 
• 7163-50-0 (4-methylphenyl)(oxo)acetic acid 
• 104-87-0 4-methyl-benzaldehyde 
• 68228-48-8 1-(p-toluoyl)-1,2,4-triazole 
• 593-75-9 methyl isocyanate 
• 14062-78-3 N,N-dimethyl-4-toluamide 
• 288-42-6 oxazol 
• 106-38-7 para-bromotoluene 

Downstream Products

• 1402228-05-0 5-(4-methylphenyl)-2-{1-(pyrimidin-2-yl)-1H-indol-2-yl}oxazole 
• 1584688-10-7 C₁₇H₁₅NO 
• 1584688-14-1 C₁₅H₁₂N₂O 
• 1584688-13-0 C₁₅H₁₂N₂O 
• 37009-57-7 2-phenyl-5-p-tolyloxazole 

Relevant articles and documents

Synthesis of Nanostructured Organosilicon Luminophores Based on Phenyloxazoles

A series of nanostructured organosilicon luminophores (NOLs) composed of a central 1,4-bis(5-phenyl-1,3-oxazol-2-yl)benzene (POPOP) acceptor chromophore and various peripheral p-terphenyl and 2,5-diphenyl-1,3-oxazole donor fragments have been synthesized for the first time using van Leusen reaction and direct palladium-catalyzed C-arylation of oxazole ring. Due to different functionalities of the silicon branching centers, NOLs with different donor-acceptor ratios have been obtained. The synthesized structures are expected to possess good optical characteristics for use in photonics and optoelectronics.

Targeted Polypharmacology: Discovery of a Highly Potent Non-Hydroxamate Dual Matrix Metalloproteinase (MMP)-10/-13 Inhibitor

Matrix metalloproteinases (MMPs) play a key role in many diseases like cancer, atherosclerosis or arthritis. Interest in MMP inhibition has been revitalized very recently as the knowledge on the underlying network of biological pathways is steadily growing. On the basis of this new insight into the relevance of MMP-10 and MMP-13 within the MMP network and the ban of hydroxamate inhibitors from clinical development, the discovery of non-hydroxamate multitarget drugs against specific MMPs is of foremost interest. Here, we disclose the discovery of a very potent and selective non-hydroxamate MMP-10/-13 inhibitor. The high potency (IC50 of 31 nM [MMP-10] and 5 nM [MMP-13]) and selectivity over MMP-1, -2, -3, -7, -8, -9, -12, and -14 enable this compound to decipher disease causing MMP networks and to generate new treatment options through targeted polypharmacology.

A One-Pot Tandem Approach for the Synthesis of 5-(Het)aryloxazoles from Substituted (Het)aryl Methyl Alcohols and Benzyl Bromides

A new modified van Leusen strategy has been developed for the synthesis of biologically significant 5-substituted oxazoles by the reaction of (het)aryl methyl alcohols or benzyl bromides as precursors with tosylmethylisocyanide (TosMIC) under basic conditions. This method is efficient, takes place under mild reaction conditions, and is tolerant of various functional groups with high yield.