143660-63-3

Upstream product

• 143660-62-2 (2S,6S,7R)-(3E)-6,7-epoxy-1-p-methoxyphenylmethoxynon-3-ene-2,9-diol 2-benzoate 
• 98-88-4 benzoyl chloride 
• 174874-19-2 (2S,6S,7R)-(3E)-9-t-butyldimethylsilyloxy-6,7-epoxy-1-p-methoxyphenylmethoxynon-3-en-2-ol 2-benzoate 
• 174874-16-9 (2S,6S,7S)-9-t-butyldimethylsilyloxy-7-chloro-1-p-methoxyphenylmethoxynon-3-yne-2,6-diol 
• 174874-17-0 (2S,6S,7R)-9-t-butyldimethylsilyloxy-6,7-epoxy-1-p-methoxyphenylmethoxynon-3-yn-2-ol 

Downstream Products

• 174874-21-6 (2S,6R,7R)-(3E)-2-benzoyloxy-6-bromo-1-p-methoxyphenylmethoxynon-3-ene-7,9-diol 9-pivaloate 
• 174874-23-8 2,2-Dimethyl-propionic acid (3R,4R)-4-bromo-3-(tert-butyl-dimethyl-silanyloxy)-5-{(2R,3S)-3-[(R)-1-methanesulfonyloxy-2-(4-methoxy-benzyloxy)-ethyl]-oxiranyl}-pentyl ester 
• 143660-65-5 2,2-Dimethyl-propionic acid (3R,4R)-4-bromo-3-(tert-butyl-dimethyl-silanyloxy)-5-{(2R,3R)-3-[(R)-1-hydroxy-2-(4-methoxy-benzyloxy)-ethyl]-oxiranyl}-pentyl ester 
• 174874-22-7 (2S,6R,7R)-(3E)-2-benzoyloxy-6-bromo-7-t-butyldimethylsilyloxy-1-p-methoxyphenylmethoxynon-3-en-9-ol 9-pivaloate 
• 143660-64-4 (2S,6R,7R)-(3E)-6-bromo-7-t-butyldimethylsilyloxy-1-p-methoxyphenylmethoxynon-3-ene-2,9-diol 9-pivaloate 

Relevant academic research and scientific papers

Total synthesis of (-)-dactylynes

The first total synthesis of (-)-dactylyne (1) and (-)-isodactylyne (2), which have been isolated from sea hare, is described in detail. Critical steps in the synthesis include a stereoselective construction as well as an intramolecular ring closure of 32, and the effective double elongation reactions (59 → 63 and 64, 67 → 68, and 70 → 71).

Total synthesis of (-)-dactylyne and (-)-isodactylyne

The first total synthesis of (-)-dactylyne (1) and (-)-isodactylyne (2), which are isolated from sea hare, is described via intermediates 3-15 and 17-18. Critical steps in the synthesis include a stereoselective construction as well as an intramolecular r