14368-32-2

Upstream product

• 93-55-0 1-phenyl-propan-1-one 
• 75-05-8 acetonitrile 
• 14904-37-1 Sodium acetonitrile 
• 124650-84-6 3-Ethyl-3-phenyl-oxirane-2-carbonitrile 

Downstream Products

• 131802-69-2 DL-HEPP 

Relevant academic research and scientific papers

Direct catalytic aldol-type reactions using RCH2CN

(Matrix presented) A copper fluoride-catalyzed cyanomethylation that can be applied to a wide range of ketones and aldehydes was developed using TMSCH2CN as a nucleophile. The reaction was extended to a conceptually more advanced copper alkoxid

Phenyl alcohol amides having anticonvulsant activity

New anticonvulsant compounds include (±)-2-hydroxy-2-phenylbutyramide and (±)-3-hydroxy-3-phenylpentamide. These homologues of (±)-4-hydroxy-4-phenylhexanamide have anticonvulsant activity as well as unexpected properties, particularly low neurotoxicity a

Alkyliron- and Alkylcobalt Reagents, V.- Anticheleselective Cyanoalkylation with Cyanoalkyl Derivatives of Iron(II), Titanium(IV) and Further Transition Metals

In intermolecular competition experiments with substrate pairs which consist of a β-functionalized ketone and a normal ketone, cyanoalkyl derivatives of Fe, Ti, Cr, and Mn prefer in every case the normal ketone ("anticheleselectivity").NC-CH2Ti(OiPr)3 (4a) and NC-CH2FeCl (3a) are the best reagents for the anticheleselective transfer of the cyanomethyl group.For the anticheleselective transfer of the cyanoisopropyl group, NC-CMe2FeCl (3b) is superior to the corresponding Ti reagents.The ability of 4a as a highly anticheleselective cyanomethylating reagent has also been demonstrated with an intramolecular competition system (diketon 13).The reasons for the observed anticheleselectivity are discussed. Key Words: Organoiron compounds / Organotitanium compounds / Cyanoalkylation

A new homologous series of anticonvulsants: Phenyl alcohol amides. Synthesis and pharmacological evaluation

The anticonvulsant activity of a homologous series of phenyl alcohol amides is described. (±)-2-Hydroxy-2-phenylbutyramide (1), (±)-3-hydroxy-3-phenylpentanamide (2) and (±)-4-hydroxy-4-phenylhexanamide (3) were prepared and tested for their anticonvulsant profile and neurotoxicity. 1, 2 and 3 exhibited a broad profile of anticonvulsant activity and a similar significant activity in the seizures provoked by maximal electroshock, pentetrazol, 4-aminopyridine, bicuculline and thiosemicarbazide, but in the strychnine and picrotoxin tests, the protection was variable. The rotarod ataxia test was used to evaluate their neurotoxicity. In this test 2 possesses the lowest neurotoxicity.

Electroreductive Ring-Opening of α,β-Epoxy Carbonyl Compounds and Their Homologues through Recyclable Use of Diphenyl Diselenide or Diphenyl Ditelluride as a Mediator

A novel access to β-hydroxy carbonyl compounds from the corresponding α,β-epoxy compounds has been attained through the recyclable use of diphenyl diselenide or diphenyl ditelluride as an electroreduction mediator in a MeOH-NaClO4-(Pt) system. α,β-Epoxy ketones are converted to the corresponding aldols in the presence of malonic esters.Similarly, α,β-epoxy esters and nitriles can be reduced to the corresponding β-hydroxy compounds in the presence of acetic acid.