143682-93-3Relevant academic research and scientific papers
Asymmetric catalytic reductive coupling of 1,3-enynes and aromatic aldehydes
Miller, Karen M.,Colby, Elizabeth A.,Woodin, Katrina S.,Jamison, Timothy F.
, p. 1533 - 1536 (2005)
Nickel-catalyzed reductive coupling reactions of 1,3-enynes and aromatic aldehydes efficiently afford conjugated dienols in excellent regioselectivity and modest enantioselectivity when conducted in the presence of catalytic amounts of a monodentate, P-chiral ferrocenyl phosphine ligand. 1-(Trimethylsilyl)-substituted enynes are shown to be effective coupling partners in these reactions, and the dienol products thus formed readily undergo protiodesilylation under mild conditions.
