14369-90-5

Upstream product

• 626-34-6 ethyl aminocrotonate 
• 74-88-4 methyl iodide 
• 14369-89-2 (±)-ethyl 2,3-dimethyl-2H-azirine-2-carboxylate 
• 609-14-3 2-acetylpropanoic acid ethyl ester 

Downstream Products

• 110146-08-2 5,6-dimethyl-2-phenyl-3-m-tolyl-3H-pyrimidin-4-one 
• 109810-48-2 3-(2-chloro-phenyl)-5,6-dimethyl-2-phenyl-3H-pyrimidin-4-one 
• 108622-77-1 2,5,6-trimethyl-3-p-tolyl-3H-pyrimidin-4-one 
• 109690-41-7 3-ethyl-5,6-dimethyl-2-phenyl-3H-pyrimidin-4-one 
• 113381-16-1 5,6-dimethyl-3-[1]naphthyl-2-phenyl-3H-pyrimidin-4-one 
• 101731-17-3 5,6-dimethyl-2,3-diphenyl-3H-pyrimidin-4-one 
• 412299-76-4 (+/-)-2-(2,5-dihydroxy-phenyl)-3-imino-2-methyl-butyric acid ethyl ester 
• 36816-92-9 (E)-3-(3-Iodo-benzoylamino)-2-methyl-but-2-enoic acid ethyl ester 
• 36816-91-8 (E)-3-(3,5-Dibromo-benzoylamino)-2-methyl-but-2-enoic acid ethyl ester 
• 36816-95-2 (E)-3-(4-Isopropyl-benzoylamino)-2-methyl-but-2-enoic acid ethyl ester 
• 36816-89-4 (E)-3-(3,4-Dichloro-benzoylamino)-2-methyl-but-2-enoic acid ethyl ester 
• 36816-93-0 (E)-3-(4-Iodo-benzoylamino)-2-methyl-but-2-enoic acid ethyl ester 
• 81818-58-8 Ethyl 2-methyl-3-N-(N'-phenylureido)-2-butenoate 
• 81818-59-9 3-Phenyl-5,6-dimethyluracil 

Relevant academic research and scientific papers

Synthesis of oxazolidin-2-ones and imidazolidin-2-ones directly from 1,3-diols or 3-amino alcohols using iodobenzene dichloride and sodium azide

A general and efficient method for the synthesis of oxazolidin-2-ones and imidazolidin-2-ones directly from 1,3-diols and 3-amino alcohols has been developed using the same reagent combination of iodobenzene dichloride (PhICl2) and sodium azide (NaN3).

SUBSTITUTED PYRIMIDINONES

Substituted pyrimidinones are provided, of the Formula (I): wherein variables are as described herein. Such compounds are ligands that may be used to modulate specific receptor activity in vivo or in vitro, and are particularly useful in the treatment of conditions associated with pathological receptor activation in humans, domesticated companion animals and livestock animals. Pharmaceutical compositions and methods for using such compounds to treat such disorders are provided, as are methods for using such ligands for receptor localization studies.

An efficient synthesis of 3-substituted 3H-pyrimidin-4-ones

(Equation presented) A novel and practical synthesis of 3-substituted 3H-pyrimidin-4-ones is described. The key step involves the cyclization of enamide esters, derived from readily available β-keto esters, with trimethylaluminum and various primary amines.

KINETICS OF CYCLIZATION OF 1-PHENYL-3-(1,2-DIMETHYL-3-OXO-1-BUTENYL)UREA AND ETHYL 2-METHYL-3-N-(N'-PHENYLUREIDO)-2-BUTENOATE

1-Phenyl-3-(1,2-dimethyl-3-oxo-1-butenyl)urea (III) has been prepared by reaction of phenyl isocyanate with 4-amino-3-methyl-3-penten-2-one (I).Ethyl 2-methyl-3-N-(N'-phenylureido)-2-butenoate (V) has been prepared by analogous reaction with ethyl 3-amino