143699-06-3

Usage

Uses

Used in Pharmaceutical Industry:
1H-Pyrazol-5-ol, 4,4'-[(4-chlorophenyl)methylene]bis[3-methyl-1-phenylis used as a key intermediate for the development of new drugs, leveraging its ability to modulate biological processes. Its complex structure allows for the potential creation of innovative pharmaceuticals that can address various medical needs.
Used in Agrochemical Industry:
In the agrochemical sector, 1H-Pyrazol-5-ol, 4,4'-[(4-chlorophenyl)methylene]bis[3-methyl-1-phenylis utilized for its potential to influence biological systems relevant to agriculture, such as pest control or crop enhancement. Its application can contribute to the development of more effective and targeted agrochemical products.
Used in Organic Synthesis:
1H-Pyrazol-5-ol, 4,4'-[(4-chlorophenyl)methylene]bis[3-methyl-1-phenylis employed as a valuable building block in organic synthesis, where its unique structure can be used to create a variety of complex organic compounds for different applications.
Used in Medicinal Chemistry:
1H-Pyrazol-5-ol, 4,4'-[(4-chlorophenyl)methylene]bis[3-methyl-1-phenylis used in medicinal chemistry for the design and synthesis of new pharmaceutical agents. Its potential to interact with biological targets makes it a promising candidate for the development of innovative treatments and therapies.

Upstream product

• 71289-10-6 4-(4-chlorobenzylidene)-5-methyl-2-phenyl-2,4-dihydro-3H-pyrazol-3-one 
• 942-32-5 5-methyl-2-phenyl-2H-pyrazol-3-ol 
• 104-88-1 4-chlorobenzaldehyde 
• 89-25-8 edaravone 
• 27420-41-3 2-hydroxy-4H-pyrido<1,2-a>pyrimidin-4-one 
• 105-45-3 acetoacetic acid methyl ester 
• 100-63-0 phenylhydrazine 
• 141-97-9 ethyl acetoacetate 

Downstream Products

• 71289-10-6 4-(4-chlorobenzylidene)-5-methyl-2-phenyl-2,4-dihydro-3H-pyrazol-3-one 
• 942-32-5 5-methyl-2-phenyl-2H-pyrazol-3-ol 

Relevant academic research and scientific papers

Stability Constants of Thorium(IV) Complexes with Aryl-bis-(5-hydroxy-3-methyl-1-phenyl-4-pyrazolyl) Methane Ligands

Stability constants of complexes of aryl-bis-(5-hydroxy-3-methyl-1-phenyl-4-pyrazolyl)methane derivatives with thorium(IV) ions were determined by the potentiometric method at 30 deg C and an ionic strength of 0.1 mol*dm-3 (KNO3) in 75

In situ decorated Mn–lysine complex on magnetic nanoparticles as a novel and reusable nanocatalyst in the synthesis of 4,4′-(arylmethylene)-bis-(3-methyl-1-phenyl-1H-pyrazol-5-ols) derivatives

In this work, we report a new and recoverable catalyst by anchoring the Mn–Lysine complex on the surface of CoFe2O4 magnetic nanoparticles through a simple, rapid and eco-friendly procedure. The successful synthesis of this nanostruc

Synthesis of sulfonated melamine-functionalized Fe3O4@SiO2@Si–(CH2)3@melamine nanoparticles and its application in the synthesis of 4,4’-(aryl methylene)bis(3-methyl-1H-pyrazol-5-ol)s and hexahydroqui

In this work, sulfonated melamine-functionalized Fe3O4@SiO2@Si-(CH2)3@melamine nanoparticles were prepared through a simple approach and characterized by energy dispersive X-ray analysis (EDX), field

Zirconium@guanine@MCM-41 nanoparticles: An efficient heterogeneous mesoporous nanocatalyst for one-pot, multi-component tandem Knoevenagel condensation–Michael addition–cyclization Reactions

MCM-41-supported nanoscale guanine bonded with Zr (IV) was prepared using sol–gel method and characterized by FT-IR, Raman, XRD, BET, TGA, EDX, ICP, AAS, X-Ray mapping, SEM and TEM techniques. This compound was employed as an efficient, chemoselectivity a

Pd(0)-guanidine?MCM-41: a very effective catalyst for rapid production of bis (pyrazolyl)methanes

In this research, a rapid, green and efficient protocol for synthesis of bis (pyrazolyl)methane derivatives in the presence of Pd(0)-guanidine?MCM-41 catalysts under solvent-free conditions by the following two methods has been reported: (i) via the one-p

Chitosan-SO3H (CTSA) an efficient and biodegradable polymeric catalyst for the synthesis of 4,4′-(arylmethylene)bis(1H-pyrazol-5-ol) and α-amidoalkyl-β-naphthol’s

An efficient, green procedure for the synthesis of 4,4′-(arylmethylene)bis(1H-pyrazol-5-ol) and α-amidoalkyl-β-naphthol’s using biodegradable polymeric catalyst chitosan-SO3H (CTSA), is operationally easy to prepare by mixing chitosan and chlor

Guanine-La complex supported onto SBA-15: A novel efficient heterogeneous mesoporous nanocatalyst for one-pot, multi-component Tandem Knoevenagel condensation–Michael addition–cyclization Reactions

In this work, we present a simple, environmentally-friendly and economical route for the preparation of a novel lanthanum (III) organometallic complex immobilized onto a highly stable mesoporous silica SBA-15 (La-guanine@SBA-15) using an inexpensive and s

Ascorbic Acid as an Eco-friendly Catalyst for the Effcient Synthesis of Bis(3-methyl-1-phenyl-1H-pyrazol-5-ols) in Aqueous Media

One-pot, multi-component reaction of 3-methyl-1-phenyl-1H-pyrazol-5(4H)-one (1) and aryl aldehydes 2 or 5-substituted indoline-2,3-diones (4a-c) in the presence of ascorbic acid as a unique catalyst in aqueous media afforded the 4, 4’-(arylmethylene)-bis(

Synthesis of a new Ni complex supported on CoFe2O4 and its application as an efficient and green catalyst for the synthesis of bis(pyrazolyl)methane and polyhydroquinoline derivatives

Effective research in green chemistry requires new and applicable synthetic techniques. In this regard, for the first time, a green method is reported for the immobilization of iminodiacetic acid-Ni complex on the surface of CoFe2O4

A simple, rapid and effective protocol for synthesis of bis(pyrazolyl)methanes using nickel–guanidine complex immobilized on MCM-41

Abstract: In this paper, a rapid, easy and very efficient method for the synthesis of bis(pyrazolyl)methanes has been reported in the presence of nickel–guanidine complex immobilized on MCM-41 (MCM-41@Gu@Ni) as a recyclable nanocatalyst. This mesoporous s