143717-83-3

Upstream product

• 98760-25-9 oxiran-2-ylmethyl benzoate 
• 98-88-4 benzoyl chloride 

Downstream Products

• 143738-30-1 5-benzyl-1-<(1'-azidomethyl-2'-benzoyloxyethoxy)methyl>uracil 
• 143717-93-5 5-benzyloxybenzyl-1-<(1'-azidomethyl-2'-benzoyloxyethoxy)methyl>uracil 
• 1234358-07-6 C₂₃H₂₈N₄O₃ 
• 1234358-12-3 C₂₁H₂₈N₄O₅ 
• 1234358-06-5 C₂₁H₃₂N₄O₃ 
• 1234358-09-8 C₁₇H₂₂N₄O₄ 
• 1234358-10-1 C₂₄H₂₈N₄O₃ 
• 1234358-11-2 C₂₃H₂₇N₅O₃ 
• 114790-16-8 3-azido-2-oxo-1-propyl benzoate 

Relevant academic research and scientific papers

Identifying Glyceraldehyde 3-Phosphate Dehydrogenase as a Cyclic Adenosine Diphosphoribose Binding Protein by Photoaffinity Protein-Ligand Labeling Approach

Cyclic adenosine diphosphoribose (cADPR), an endogenous nucleotide derived from nicotinamide adenine dinucleotide (NAD+), mobilizes Ca2+ release from endoplasmic reticulum (ER) via ryanodine receptors (RyRs), yet the bridging protein(s) between cADPR and RyRs remain(s) unknown. Here we synthesized a novel photoaffinity labeling (PAL) cADPR agonist, PAL-cIDPRE, and subsequently applied it to purify its binding proteins in human Jurkat T cells. We identified glyceraldehyde 3-phosphate dehydrogenase (GAPDH) as one of the cADPR binding protein(s), characterized the binding affinity between cADPR and GAPDH in vitro by surface plasmon resonance (SPR) assay, and mapped cADPR's binding sites in GAPDH. We further demonstrated that cADPR induces the transient interaction between GAPDH and RyRs in vivo and that GAPDH knockdown abolished cADPR-induced Ca2+ release. However, GAPDH did not catalyze cADPR into any other known or novel compound(s). In summary, our data clearly indicate that GAPDH is the long-sought-after cADPR binding protein and is required for cADPR-mediated Ca2+ mobilization from ER via RyRs.

The synthesis of densely functionalised α-acyloxy enaminals and enaminones: Via a novel homogeneous silver(i) catalysed rearrangement

A synthesis of densely functionalised α-acyloxy enaminals and enaminones via a novel homogeneous silver(i) catalyzed rearrangement of 1-acyloxy-3-azido ketones is reported. This silver catalyzed reaction involves an internal redox process comprised of fou

IPSC Neuronal Assay Identifies Amaryllidaceae Pharmacophore with Multiple Effects against Herpesvirus Infections

The Amaryllidaceae alkaloid trans-dihydrolycoricidine 7 and three analogues 8-10 were produced via asymmetric chemical synthesis. Alkaloid 7 proved superior to acyclovir, the current standard for herpes simplex virus, type 1 (HSV-1) infection. Compound 7

Library of 1,4-disubstituted 1,2,3-triazole analogs of oxazolidinone RNA-binding agents

The design and synthesis of small molecules that target RNA is immensely important in antibacterial therapy. We had previously reported on the RNA binding of a series of 4,5-disubstituted 2-oxazolidinones that bind to a highly conserved bulge region of bacterial RNA. This biological target T box antitermination system, which is found mainly in Gram-positive bacteria, regulates the expression of several amino acid related genes. In an effort to amplify our library, we have prepared a library of 1,4-disubstituted 1,2,3-triazole analogs that entails an isosteric replacement of the oxazolidinone nucleus. The synthesis of the new analogs was enhanced via copper(I) catalysis of an azide and alkyne cycloaddition reaction. A total of 108 1,4-disubstituted 1,2,3-triazole compounds have been prepared. All compounds were evaluated as RNA binding agents.

2,2'-Bipyridinium chlorochromate/m-chloroperbenzoic acid-mediated cleavage of cyclic acetals to hydroxyesters

Benzylidene acetals are cleaved to hydroxyesters by means of a reagent system composed of 2,2'-bipyridinium chlorochromate (BPCC) and m-chloroperbenzoic acid. Oxidative cleavage of a 4,6-O-benzylidene glucose derivative affords a 6-O-benzoyl derivative.