143724-71-4Relevant academic research and scientific papers
Hypoglycemic and hypolipidemic dual activities of extracts and flavonoids from Desmodium caudatum and an efficient synthesis of the most potent 8-prenylquercetin
Sun, Hua,Xiao, Zhiyi,Zhang, Xiaoting,Zhang, Xinying,Zhang, Yinan
, (2021/11/23)
Since glucolipid metabolism disorders is often the mono-target therapy fails in managing blood glucose and lipid levels and the other complications, it is urgent and necessary to seek for the new potential drugs or functional food acting on multi-targets.
Regioselective synthesis of C-prenylated flavonoids via intramolecular [1,3] or [1,5] shift reaction catalyzed by acidic clays
Li, Wei,Shu, Liang,Liu, Kexiong,Wang, Qiuan
supporting information, (2019/09/17)
Prenyl side chain and dihydropyrano skeleton exists in many natural and synthetic biologically active flavonoids. A highly efficient and regioselective method for the synthesis of C-prenylated flavonoids via intramolecular [1,3] or [1,5] shift reaction of
Synthesis, α-glucosidase inhibitory and molecular docking studies of prenylated and geranylated flavones, isoflavones and chalcones
Sun, Hua,Li, Yashan,Zhang, Xiaoting,Lei, Yanan,Ding, Weina,Zhao, Xue,Wang, Haomeng,Song, Xiaotong,Yao, Qingwei,Zhang, Yongmin,Ma, Ying,Wang, Runling,Zhu, Tao,Yu, Peng
, p. 4567 - 4571 (2015/10/12)
Three series of prenylated and/or geranylated flavonoids were synthesized and evaluated for their α-glucosidase inhibitory activity. The 3′,5′-digeranylated chalcone (16) was identified as a new α-glucosidase inhibitor whose activity (IC50 = 0.
Effects of flavonoids on cell proliferation and caspase activation in a human colonic cell line HT29: An SAR study
Daskiewicz, Jean-Baptiste,Depeint, Flore,Viornery, Lionel,Bayet, Christine,Comte-Sarrazin, Geraldine,Comte, Gilles,Gee, Jennifer M.,Johnson, Ian T.,Ndjoko, Karine,Hostettmann, Kurt,Barron, Denis
, p. 2790 - 2804 (2007/10/03)
A library of 42 natural and synthetic flavonoids has been screened for their effect on cell proliferation and apoptosis in a human colonic cell line (HT-29). Examples of different classes of flavonoids have been screened, and the effects of hydroxylation, methoxylation and/or C-alkylation at various positions in the A- and B-rings have been assessed. Flavones and flavonols possess greater antiproliferative activity than chalcones and flavanones. With respect to structural modification of flavonoids, C-isoprenylation was by far the most effective, with substitution at the 8-position and longer chains, such as geranyl giving the best results. Finally, most compounds that significantly reduced cell survival also increased caspase activity, suggesting that at least part of their antiproliferative activity might be attributable to an apoptotic response.
