143724-67-8Relevant articles and documents
Hypoglycemic and hypolipidemic dual activities of extracts and flavonoids from Desmodium caudatum and an efficient synthesis of the most potent 8-prenylquercetin
Sun, Hua,Xiao, Zhiyi,Zhang, Xiaoting,Zhang, Xinying,Zhang, Yinan
, (2021/11/23)
Since glucolipid metabolism disorders is often the mono-target therapy fails in managing blood glucose and lipid levels and the other complications, it is urgent and necessary to seek for the new potential drugs or functional food acting on multi-targets.
Potent, selective, allosteric inhibition of human plasmin by sulfa non-saccharide glycosaminoglycan mimetics
Afosah, Daniel K.,Al-Horani, Rami A.,Sankaranarayanan, Nehru Viji,Desai, Umesh R.
, p. 641 - 657 (2017/02/05)
Although plasmin inhibitors could be used in multiple disorders, their use has been restricted to preventing blood loss in hemostatic dysregulation because of poor efficacy and adverse effects of current agents. We reasoned that a new class of direct inhi
Synthesis, α-glucosidase inhibitory and molecular docking studies of prenylated and geranylated flavones, isoflavones and chalcones
Sun, Hua,Li, Yashan,Zhang, Xiaoting,Lei, Yanan,Ding, Weina,Zhao, Xue,Wang, Haomeng,Song, Xiaotong,Yao, Qingwei,Zhang, Yongmin,Ma, Ying,Wang, Runling,Zhu, Tao,Yu, Peng
, p. 4567 - 4571 (2015/10/12)
Three series of prenylated and/or geranylated flavonoids were synthesized and evaluated for their α-glucosidase inhibitory activity. The 3′,5′-digeranylated chalcone (16) was identified as a new α-glucosidase inhibitor whose activity (IC50 = 0.