1437304-85-2

Basic information

• Product Name: 1-{3-[(4-hydroxy-8-nitroquinazolin-5-yl)amino]phenyl}-3-[3-(trifluoromethyl)phenyl]urea
• CAS NO: 1437304-85-2
• Molecular Weight: 484.394
• Mol File: 1437304-85-2.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 1-{3-[(4-hydroxy-8-nitroquinazolin-5-yl)amino]phenyl}-3-[3-(trifluoromethyl)phenyl]urea(CAS DataBase Reference)
• NIST Chemistry Reference: 1-{3-[(4-hydroxy-8-nitroquinazolin-5-yl)amino]phenyl}-3-[3-(trifluoromethyl)phenyl]urea(1437304-85-2)
• EPA Substance Registry System: 1-{3-[(4-hydroxy-8-nitroquinazolin-5-yl)amino]phenyl}-3-[3-(trifluoromethyl)phenyl]urea(1437304-85-2)

Safety Data

• Hazardous Substances Data: 1437304-85-2(Hazardous Substances Data)

Upstream product

• 68621-88-5 (3-aminophenyl)carbamic acid tert-butyl ester 
• 1445768-17-1 tert-butyl 3-(3-(3-(trifluoromethyl)phenyl)ureido)phenylcarbamate 
• 108-45-2 m-phenylenediamine 
• 400784-50-1 4-hydroxy-5-chloro-8-nitro-quinazoline 
• 1041510-67-1 1-(3-aminophenyl)-3-(3-(trifluoromethyl)phenyl)urea 
• 329-01-1 1-isocyanato-3-trifluoromethyl-benzene 

Relevant articles and documents

A [...] urea and its preparation and use

The invention discloses quinazoline arylurea compounds and a preparation method and an application thereof, wherein the quinazoline arylurea compounds have a general formula I. The new compound with quinazolinyl and aryl-substituted urea shows extremely high activity in suppressing the growth of tumor cells, and particularly realizes an obvious effect in suppressing the growth of VEGFR high-expression HUVEC cells, wherein half of the suppression IC50 values can reach 1.8 mu g/mL. The invention also provides a preparation method of the compounds.