1445768-17-1

Basic information

• Product Name: tert-butyl 3-(3-(3-(trifluoromethyl)phenyl)ureido)phenylcarbamate
• CAS NO: 1445768-17-1
• Molecular Weight: 395.381
• Mol File: 1445768-17-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: tert-butyl 3-(3-(3-(trifluoromethyl)phenyl)ureido)phenylcarbamate(CAS DataBase Reference)
• NIST Chemistry Reference: tert-butyl 3-(3-(3-(trifluoromethyl)phenyl)ureido)phenylcarbamate(1445768-17-1)
• EPA Substance Registry System: tert-butyl 3-(3-(3-(trifluoromethyl)phenyl)ureido)phenylcarbamate(1445768-17-1)

Safety Data

• Hazardous Substances Data: 1445768-17-1(Hazardous Substances Data)

Upstream product

• 68621-88-5 (3-aminophenyl)carbamic acid tert-butyl ester 
• 329-01-1 1-isocyanato-3-trifluoromethyl-benzene 
• 108-45-2 m-phenylenediamine 
• 24424-99-5 di-tert-butyl dicarbonate 

Downstream Products

• 1437304-85-2 1-{3-[(4-hydroxy-8-nitroquinazolin-5-yl)amino]phenyl}-3-[3-(trifluoromethyl)phenyl]urea 
• 1041510-67-1 1-(3-aminophenyl)-3-(3-(trifluoromethyl)phenyl)urea 

Relevant articles and documents

Novel 5-anilinoquinazoline-8-nitro derivatives as inhibitors of VEGFR-2 tyrosine kinase: Synthesis, biological evaluation and molecular docking

Vascular endothelial growth factor receptor-2 (VEGFR-2) kinase inhibition is a well-established strategy to promptly tackle tumor growth by suppression of angiogenesis. We report herein a series of 5-anilinoquinazoline derivatives substituted by 1,3-disubstituted urea. All the newly synthesized compounds described were evaluated for VEGFR-2 kinase inhibition and antiproliferative activity against various cancer cells. The novel 1-aryl, 3-aryl-disubstituted urea quinazolines were effective VEGFR-2 kinase inhibitors with in vitro IC 50 values in the submicromolar range (compound 6f, IC50 12.0 nM), but showed a weak to moderate inhibitory activity on cancer cells. Molecular interactions of the compounds were studied using molecular docking studies. The Royal Society of Chemistry 2013.