1437323-99-3

Upstream product

• 13425-93-9 6,7-dimethoxyquinoline-4-ol 
• 6315-89-5 3,4-dimethoxyaniline 
• 35654-56-9 6,7-dimethoxy-4-chloroquinoline 
• 163733-99-1 4-amino-2,3-difluoro-phenol 
• 771-69-7 2,3,4-trifluoronitrobenzene 
• 868735-81-3 1-(benzyloxy)-2.3-difluoro-4-nitrobenzene 
• 213699-53-7 5-(((3,4-dimethoxyphenyl)amino)methylene)-2,2-dimethyl-1,3-dioxane-4,6-dione 
• 666734-51-6 6,7-dimethyloxy-4-bromoquinoline 

Relevant academic research and scientific papers

SUBSTITUTED QUINOLINE COMPOUNDS AND METHODS OF USE

The present invention provides novel substituted quinoline compounds, pharmaceutical acceptable salts and formulations thereof useful in modulating the protein tyrosine kinase activity, and in modulating cellular activities such as proliferation, differentiation, apoptosis, migration and invasion. The invention also provides pharmaceutically acceptable compositions comprising such compounds and methods of using the compositions in the treatment of hyperproliferative disorders in mammals, especially humans.

URACIL DERIVATIVES AS AXL AND C-MET KINASE INHIBITORS

The present invention provides compounds of Formula I, or pharmaceutically acceptable salt forms thereof, wherein Ra, Rb, Rc, Rd, D, W, R1a, R1b, R1c,Y, R3, X, E and G are as defined herein, methods of treatment and uses thereof.