143745-11-3

Basic information

• Product Name: N^α-(2-desamino-2-methyl-5-fluoro-5,8-dideazaisopterroyl)-L-ornithine
• Synonyms: N^α-(2-desamino-2-methyl-5-fluoro-5,8-dideazaisopterroyl)-L-ornithine
• CAS NO: 143745-11-3
• Molecular Weight: 441.462
• Mol File: 143745-11-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: N^α-(2-desamino-2-methyl-5-fluoro-5,8-dideazaisopterroyl)-L-ornithine(CAS DataBase Reference)
• NIST Chemistry Reference: N^α-(2-desamino-2-methyl-5-fluoro-5,8-dideazaisopterroyl)-L-ornithine(143745-11-3)
• EPA Substance Registry System: N^α-(2-desamino-2-methyl-5-fluoro-5,8-dideazaisopterroyl)-L-ornithine(143745-11-3)

Safety Data

• Hazardous Substances Data: 143745-11-3(Hazardous Substances Data)

Upstream product

• 13650-49-2 N^δ-(tert-butoxycarbonyl)-L-ornithine 
• 1027238-11-4 4-{[(5-Fluoro-2-methyl-4-oxo-3,4-dihydro-quinazolin-6-yl)-(2,2,2-trifluoro-acetyl)-amino]-methyl}-benzoic acid 
• 143745-27-1 methyl 2-desamino-2-methyl-5-fluoro-5,8-dideazaisopteroate 
• 143745-28-2 2-desamino-2-methyl-5-fluoro-5,8-dideazaisopteroic acid 
• 143745-26-0 6-amino-3,4-dihydro-5-fluoro-2-methyl-4-oxoquinazoline 
• 143745-24-8 3,4-dihydro-5-fluoro-2-methyl-4-oxoquinazoline 
• 137553-47-0 4-amino-5-fluoro-2-methylquinazoline 
• 143745-29-3 N^δ-(tert-butyloxycarbonyl)-N^α-(2-desamino-2-methyl-5-fluoro-5,8-dideazaisopterroyl)-L-ornithine 

Relevant articles and documents

Inhibition of hog liver folylpolyglutamate synthetase by 5-substituted 5,8-dideaza analogues of folic acid bearing a terminal L-ornithine residue

Five new N(α)-(5,8-dideazapteroyl)-L-ornithines have been prepared using multistep synthetic sequences. These include N(α)-[5-(trifluoromethyl)-5,8- dideazapteroyl]-L-ornithine, 3, as well as N(α)-[5-(trifluoromethyl)-5,8- dideazaisopteroyl]-L-ornithine,