143745-24-8Relevant articles and documents
Transition-metal free synthesis of quinazolinones via tandem cyclization of 2-halobenzoic acids with amidines
Tiwari, Abhishek R.,Bhanage, Bhalchandra M.
, p. 57235 - 57239 (2015)
A simple protocol for the synthesis of quinazoline-4(3H)-ones by tandem cyclization of 2-halobenzoic acids with amidines has been developed by using KOH as a base in DMSO at 120 °C. This protocol does not involve the use of any transition-metals or ligands or any coupling reagents. The present methodology is operationally simple, scalable and varieties of quinazolinone derivatives were obtained in good to excellent yields.