14376-84-2Relevant academic research and scientific papers
I2-Promoted [4 + 2] cycloaddition of: In situ generated azoalkenes with enaminones: Facile and efficient synthesis of 1,4-dihydropyridazines and pyridazines
Baell, Jonathan B.,Feng, Jiajun,He, Tiantong,Huang, Fei,Xie, Yuxing,Yu, Yang
, p. 9483 - 9493 (2020/12/15)
A facile and efficient strategy for the synthesis of 1,4-dihydropyridazines and pyridazines through I2-promoted [4 + 2] cycloaddition of in situ generated azoalkenes with enaminones has been developed. The switch in selectivity is attributed to the judici
Highly Site-Selective Metal-Free C-H Acyloxylation of Stable Enamines
Wang, Fei,Sun, Wangbing,Wang, Yixin,Jiang, Yaojia,Loh, Teck-Peng
supporting information, p. 1256 - 1260 (2018/02/23)
A highly site-selective acyloxylation of stable enamines with PhI(OAc)2 under metal-free conditions to afford (E)-vinyl acetate derivatives in good to excellent yields is described. Depending on the judicious choice of the solvent system, either the α- or β-site-selective product could be obtained with high selectivity. For the α-site-selective product, the rearranged amide compound is obtained as the major product. This reaction proceeds under mild reaction conditions (room temperature, metal-free, and open-flask) and features a broad substrate scope.
Silver-catalyzed efficient synthesis of enaminones from propargyl alcohols and amines
Li, Mengshun,Fang, Dongmei,Geng, Feng,Dai, Xianping
supporting information, p. 4747 - 4749 (2017/11/28)
Enaminones are used as the key intermediates to construct heterocyclic compounds with various bioactivities. In this study, a simple and efficient approach for the synthesis of enaminones via amination of propargyl alcohols was developed. Under the catalysis of Ag2CO3, the reaction proceeded smoothly to afford the desired products in good yields. Preliminary mechanism experiments showed that Ag2CO3 played an essential role in the procedure of the reaction.
Transformation of α-substituted propanols into γ-amino alcohols through nickel-catalyzed amination on the terminal γ-carbon of propanols
Ueno, Satoshi,Usui, Kazumi,Kuwano, Ryoichi
supporting information; experimental part, p. 1303 - 1307 (2011/07/08)
A nickel-phosphine complex was found to be effective as the catalyst for the transformation of alcohols into β-enaminones, which was successively converted into γ-amino alcohols by a conventional reductant. The sequential transformation is equivalent to the carbon-nitrogen bond formation at the γ-position of saturated alcohols. Georg Thieme Verlag Stuttgart · New York.
