14377-99-2Relevant academic research and scientific papers
Solvent-free condensation of arylacetonitrile with aldehydes
Guillot, Régis,Loupy, André,Meddour, Abdelkrim,Pellet, Michèle,Petit, Alain
, p. 10129 - 10137 (2007/10/03)
The condensation of a series of arylacetonitriles with aldehydes can be carried out by mixing equivalent amounts of reagents with neat powdered KOH at room temperature for 3-60 min depending on the aldehyde steric hindrance. At higher temperature (110°C), yields were generally higher and purity increased within very short reaction times (1-5 min). With pentamethylphenylacetonitrile, a phase transfer agent was necessary to give a satisfactory yield.
Water-soluble calixarenes as new inverse phase-transfer catalysts. Their application to aldol-type condensation and Michael addition reactions in water
Shimizu, Shoichi,Shirakawa, Seiji,Suzuki, Takashi,Sasaki, Yasuyuki
, p. 6169 - 6173 (2007/10/03)
Aldol-type condensation and Michael addition reactions of activated methyl and methylene compounds in aqueous NaOH solution have been developed without the need for any added organic solvents. The water-soluble calix[n]arenes, which contain trimethylammon
