1437798-92-9Relevant academic research and scientific papers
Copper-Catalyzed Aerobic Cascade Oxidative Coupling/Cyclization for the Construction of 1,4-Dihydropyridine Derivatives
Zhu, Zhi-Qiang,Xie, Zong-Bo,Le, Zhang-Gao
, p. 9449 - 9454 (2016)
An efficient copper-catalyzed cascade cyclization reaction for the preparation of polysubstituted 1,4-dihydropyridines between N-arylglycine esters and 1,3-dicarbonyl compounds using molecular oxygen as the terminal oxidant has been described. Various N-arylglycine esters 1 and 1,3-dicarbonyl compounds 2 were able to undergo the cascade reaction smoothly to afford the desired products 3 in satisfactory yields. The cascade reaction has the advantages of good functional group tolerance and mild reaction conditions. A possible mechanism has also been proposed on the basis of control experiments.
Multicomponent reactions leading to symmetric and asymmetric multi-substituted 1,4-dihydropyridines on montmorillonite
Liu, Yu-Peng,Liu, Jin-Ming,Wang, Xin,Cheng, Tie-Ming,Li, Run-Tao
, p. 5242 - 5247 (2013/06/27)
Highly functionalized multi-substituted symmetric and asymmetric 1,4-dihydropyridines were concisely synthesized in moderate to good yields via one-pot multicomponent reactions (MCRs) of β-dicarbonyl compounds, aldehydes and amines at room temperature on
