143810-77-9

Upstream product

• 2786-07-4 2-thienyl lithium 
• 1517-82-4 (-)-menthyl p-toluenesulfinate 
• 5713-61-1 thiophen-2-yl magnesium bromide 
• 190448-84-1 (1S,5R,7R)-10,10-Dimethyl-4-((R)-toluene-4-sulfinyl)-3-thia-4-aza-tricyclo[5.2.1.0^1,5]decane 3,3-dioxide 
• 10439-23-3 4-methylbenzenesulfinyl chloride 
• 188290-36-0 thiophene 

Relevant academic research and scientific papers

Asymmetric synthesis of chiral sulfoxides and sulfinimines by using N-sulfinylsultam

Bornane-10,2-sultam 1 is stereoselectively converted by DMAP-assisted sulfinylation to diastereomerically pure (2R)-N-[(R)-p-tolylsulfinyl]-bornane-10,2-sultam 2 in 77% yield. The crystalline sulfinylating agent 2 reacts with a variety of nucleophiles to afford sulfoxides 3 and sulfinimines 5 in excellent yields and enantioselectivities.

Preparation of optically active 2-(or 3)(p-tolylsulfinyl)-3(or 2)furyl- or thienylcarboxaldehydes

The preparation of the four enantiomerically pure title compounds is described by reaction of (I)-(-)-Ss-menthyl-p-toluenesulfinate on furan or thiophene precursors.

Syntheses of Enantiomerically Pure Furyl and Thienyl p-Tolyl Sulfoxides

We report a highly enantioselective reaction of Grignard reagents, derived from simple furans or thiophene, with (-)-(S)-menthylsulfinate to give in high yield enantiomerically pure furyl and thienylsulfoxides.