143814-44-2Relevant academic research and scientific papers
A Simple and Efficient Synthesis of the Naphthoate Moiety of Neocarzinostatin Chromophore
Takahashi, Kazunobu,Suzuki, Toshio,Hirama, Masahiro
, p. 4603 - 4604 (1992)
A six-step synthesis of 2-hydroxy-7-methoxy-5-methylnaphthalene-1-carboxylic acid (2), the naphthoate moiety of neocarzinostatin chromophore (1), has been achieved. Key Words: Neocarzinostatin; Chromophore; Synthesis; 2-Hydroxy-7-methoxy-5-methylnaphthalene-1-carboxylic acid
Synthesis and Binding of Simple Neocarzinostatin Chromophore Analogues to the Apoprotein
Takahashi, Kazunobu,Tanaka, Toshiyuki,Suzuki, Toshio,Hirama, Masahiro
, p. 1327 - 1340 (1994)
Synthetic analogues (3-5, 8-10) of neocarzinostatin chromophore (1) are found to bind to the apoprotein with high affinity.Their binding energies suggest that the naphthoate moiety of 1 is essential for the binding, and that the C5-CH3 and C7-OCH3 groups are necessary for the high affinity.
