Synthesis and Binding of Simple Neocarzinostatin Chromophore Analogues to the Apoprotein

Article abstract of DOI:10.1016/S0040-4020(01)80621-9

Synthetic analogues (3-5, 8-10) of neocarzinostatin chromophore (1) are found to bind to the apoprotein with high affinity.Their binding energies suggest that the naphthoate moiety of 1 is essential for the binding, and that the C5-CH3 and C7-OCH3 groups are necessary for the high affinity.