1438234-19-5

Basic information

• Product Name: (E)-ethyl 4-([1,1'-biphenyl]-4-ylimino)-6-fluoro-1-methyl-1,4-dihydroquinoline-3-carboxylate
• CAS NO: 1438234-19-5
• Molecular Weight: 400.452
• Mol File: 1438234-19-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (E)-ethyl 4-([1,1'-biphenyl]-4-ylimino)-6-fluoro-1-methyl-1,4-dihydroquinoline-3-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: (E)-ethyl 4-([1,1'-biphenyl]-4-ylimino)-6-fluoro-1-methyl-1,4-dihydroquinoline-3-carboxylate(1438234-19-5)
• EPA Substance Registry System: (E)-ethyl 4-([1,1'-biphenyl]-4-ylimino)-6-fluoro-1-methyl-1,4-dihydroquinoline-3-carboxylate(1438234-19-5)

Safety Data

• Hazardous Substances Data: 1438234-19-5(Hazardous Substances Data)

Upstream product

• 71083-00-6 ethyl 6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylate 
• 18856-68-3 diethyl N,N-dimethylaminomethylenemalonate 
• 371-40-4 4-fluoroaniline 
• 77779-49-8 4-chloro-6-fluoroquinoline-3-carboxylic acid ethyl ester 

Relevant articles and documents

Quinolin-4(1 H)-imines are potent antiplasmodial drugs targeting the liver stage of malaria

We present a novel series of quinolin-4(1H)-imines as dual-stage antiplasmodials, several-fold more active than primaquine in vitro against Plasmodium berghei liver stage. Among those, compounds 5g and 5k presented low nanomolar IC50 values. The compounds are metabolically stable and modulate several drug targets. These results emphasize the value of quinolin-4(1H)-imines as a new chemotype and their suitable properties for further drug development.