159957-01-4

Basic information

• Product Name: 3,4-Difluoro-β,β'-dibromostyrene
• Synonyms: 3,4-Difluoro-β,β'-dibromostyrene
• CAS NO: 159957-01-4
• Molecular Weight: 297.925
• Mol File: 159957-01-4.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 3,4-Difluoro-β,β'-dibromostyrene(CAS DataBase Reference)
• NIST Chemistry Reference: 3,4-Difluoro-β,β'-dibromostyrene(159957-01-4)
• EPA Substance Registry System: 3,4-Difluoro-β,β'-dibromostyrene(159957-01-4)

Safety Data

• Hazardous Substances Data: 159957-01-4(Hazardous Substances Data)

Upstream product

• 558-13-4 carbon tetrabromide 
• 34036-07-2 3,4 difluorobenzaldehyde 

Downstream Products

• 143874-13-9 4-ethynyl-1,2-difluorobenzene 
• 159957-02-5 2-(3,4-Difluorophenyl)-1-bromoacetylene 

Relevant articles and documents

Discovery and Characterization of Pure RhlR Antagonists against Pseudomonas aeruginosa Infections

Pseudomonas aeruginosa (P. aeruginosa) is an opportunistic human pathogen that forms biofilms and produces virulence factors via quorum sensing (QS). Blocking the QS system in P. aeruginosa is an excellent strategy to reduce biofilm formation and the production of virulence factors. RhlR plays an essential role in the QS system of P. aeruginosa. We synthesized 55 analogues based on the chemical structure of 4-gingerol and evaluated their RhlR inhibitory activities using the cell-based reporter strain assay. Comprehensive structure-activity relationship studies identified the alkynyl ketone 30 as the most potent RhlR antagonist. This compound displayed selective RhlR antagonism over LasR and PqsR, strong inhibition of biofilm formation, and reduced production of virulence factors in P. aeruginosa. Furthermore, the survival rate of Tenebrio molitor larvae treated with 30 in vivo greatly improved. Therefore, compound 30, a pure RhlR antagonist, can be utilized for developing QS-modulating molecules in the control of P. aeruginosa infections.

Synthesis and Physical Properties of Asymmetric Diphenyldiacetylenic Liquid Crystals

Fifty-six asymmetric diphenyl-diacetylene liquid crystal homologs including dialkyl, alkyl-alkoxy, cyano-alkyl, chloro-alkyl, fluoro-alkyl, difluoro-alkyl, lateral chloro-substituted fluoro-alkyl (or alkoxy), lateral fluoro-substituted asymmetric dialkyl, and vinyl-alkyl are synthesized and their physical properties evaluated.Among these asymmetric diphenyl-diacetylene liquid crystals, many dialkyl homologs exhibit low melting point, wide nematic range, and low heat of fusion.They are ideal host candidates for formulating eutectic mixtures.The polar groups make important contributions to the phase transition temperature, dielectric anisotropy, refractive indices and viscosity.Detailed effects depend on the position of the substitution.These new liquid-crystals compounds and mixtures are particularly useful for electro-optic modulation of infrared radiation. - Keywords: Diphenyl-diacetylenes, eutectic mixtures, electro-optic modulation, physical properties