14389-06-1

Usage

Uses

Used in Pharmaceutical Industry:
5-CHLORO-7-METHYLISATIN is used as a building block for the synthesis of various pharmaceuticals due to its diverse biological activities and synthetic versatility. It can be used in the development of new drugs with antimicrobial, antiviral, anticancer, and anti-inflammatory properties.
Used in Agrochemical Industry:
5-CHLORO-7-METHYLISATIN is used as a building block for the synthesis of various agrochemicals, such as pesticides and herbicides, due to its antimicrobial and other biological properties. It can contribute to the development of new agrochemicals with improved efficacy and selectivity.
Used in Drug Development:
5-CHLORO-7-METHYLISATIN is used as a starting material in the development of new drugs with potential therapeutic applications. Its diverse pharmacological profile and synthetic versatility make it a valuable compound for designing and synthesizing novel drug candidates.
Used in Medicinal Chemistry Research:
5-CHLORO-7-METHYLISATIN is used as a research tool in medicinal chemistry to study its biological activities and explore its potential as a lead compound for drug discovery. Its wide range of biological properties makes it an interesting target for research in various therapeutic areas.
Used in Chemical Synthesis:
5-CHLORO-7-METHYLISATIN is used as a synthetic intermediate in the preparation of various organic compounds and derivatives. Its unique structure and reactivity make it a valuable building block for the synthesis of complex organic molecules and pharmaceutical agents.

InChI:InChI=1/C9H6ClNO2/c1-4-2-5(10)3-6-7(4)11-9(13)8(6)12/h2-3H,1H3,(H,11,12,13)

Upstream product

• 13208-93-0 N-(4-chloro-2-methylphenyl)-2-(hydroxyimino)acetamide 
• 95-53-4 o-toluidine 
• 1127-59-9 7-methyl-1H-indole-2,3-dione 
• 95-69-2 4-chloro-2-methylbenzeneamine 
• 13208-93-0 hydroxyimino-acetic acid-(4-chloro-2-methyl-anilide) 

Downstream Products

• 20776-67-4 2-amino-5-chloro-3-methylbenzoic acid 
• 79101-83-0 2-amino-3-methyl-5-chlorobenzoic acid methyl ester 
• 85778-42-3 6-Chloro-3-hydroxy-7-methyl-3-(2-oxo-2-phenyl-ethyl)-1,3-dihydro-indol-2-one 
• 342017-92-9 2-(4-bromo-phenyl)-6-chloro-8-methyl-quinoline-4-carboxylic acid 
• 342017-89-4 2-(4-bromo-phenyl)-6-chloro-8-methyl-quinoline-4-carbonitrile 
• 342017-87-2 [2-(4-bromo-phenyl)-6-chloro-8-methyl-quinolin-4-yl]-methanol 
• 342017-85-0 2-(4-bromo-phenyl)-6-chloro-8-formyl-quinoline-4-carboxylic acid methyl ester 
• 342017-82-7 8-bromomethyl-2-(4-bromo-phenyl)-6-chloro-quinoline-4-carboxylic acid methyl ester 
• 342017-84-9 2-(4-bromo-phenyl)-6-chloro-8-dibromomethyl-quinoline-4-carboxylic acid methyl ester 

Relevant academic research and scientific papers

AN EFFICIENT NEW PROCESS FOR SYNTHESIS OF 2-AMINO-5-CHLORO-N-,3-DIMETHYLBENZAMIDE

Described herein are novel methods of synthesizing 2-amino-5-chloro-N,3- dimethylbenzamide. Compounds prepared by the methods disclosed herein are useful for preparation of certain anthranilamide compounds that are of interest as insecticides, such as, for example, the insecticides chlorantraniliprole and cyantraniliprole.

Single step regioselective cyclization and chlorination of hydroxyamino-N-(2-methylphenyl)acetamide to 5-chloro-7-methylindoline-2,3-dione

A one-pot process for the manufacture of 5-chloro-7-methylindoline-2,3-dione starting from 2-hydroxyimino-N-(2-methylphenyl)acetamide via tandem cyclization in sulfuric acid and acetic acid, followed by in-situ chlorination with sulfur dioxide and chlorine gas in high regioselectivity and yield.

Preparation method of 2-amino-3-methyl-5-chlorobenzoic acid

The invention belongs to the technical field of organic synthesis, and particularly relates to a preparation method of 2-amino-3-methyl-5-chlorobenzoic acid. The preparation method provided by the invention comprises the steps of mixing m-toluic acid and nitric acid, and carrying out nitration reaction to obtain 2-nitro-3-methyl benzoic acid, wherein the mass concentration of the nitric acid is 60-75%; mixing the 2-nitro-3-methyl benzoic acid, a hydrogenation reduction reaction solvent and a hydrogenation catalyst, and carrying out hydrogenation reduction reaction in a hydrogen atmosphere to obtain 2-amino-3-methyl benzoic acid; and mixing the 2-amino-3-methyl benzoic acid, a chlorination reagent, benzoyl peroxide and a chlorination reaction solvent, and carrying out a chlorination reaction to obtain the 2-amino-3-methyl-5-chlorobenzoic acid. The preparation method provided by the invention has the advantages of cheap and easily available reaction raw materials, high product yield and high purity, and is easy for industrial production.

Chlorination of isatins with trichloroisocyanuric acid

Isatin and its derivatives have been extensively reported in the literature as having range of potential pharmacological compounds. The Sandmeyer method is the most widely used for isatin synthesis and furnishes different substituted isatins, usually with high yields. Although efficient, the Sandmeyer route has certain limitations, such as the formation of a mixture of regiosiomers and low yields depending on the type and position of the substituent. Thus, overcome these limitations, it is preferable that some derivative isatins be obtained by alternative methods. This article has investigated the chlorination of isatin derivatives using trichloroisocyanuric acid [1,3,5-trichloro- 1,3,5-triazine-2,4,6-(1H,3H,5H)-trione or TCCA] at different reaction conditions.

Quinoline-3-carbothioamides and related compounds as novel immunomodulating agents

A series of quinoline-3-carbothioamides and their analogues was prepared via four synthetic routes and evaluated for their antinephritic and immunomodulating activities. The optimal compound 9g strongly inhibited the T-cell independent antibody production in mice immunized with TNP-LPS and was highly effective in two nephritis models, namely chronic graft-versus-host disease and autoimmune MRL/l mice.