342017-84-9Relevant articles and documents
A series of quinoline analogues as potent inhibitors of C. albicans prolyl tRNA synthetase
Yu, Xiang Y.,Hill, Jason M.,Yu, Guixue,Yang, Yifeng,Kluge, Arthur F.,Keith, Dennis,Finn, John,Gallant, Paul,Silverman, Jared,Lim, Audrey
, p. 541 - 544 (2007/10/03)
A series of quinoline inhibitors of C. albicans prolyl tRNA synthetase was identified. The most potent analogue, 2-(4bromo-phenyl)-6-chloro-8-methyl-4-quinolinecarboxylic acid, showed IC50=5 nM (Ca. ProRS) with high selectivity over the human enzyme.