1439358-24-3

Basic information

• Product Name: (4-benzenesulfonylphenyl)carbamic acid phenyl ester
• Synonyms: (4-benzenesulfonylphenyl)carbamic acid phenyl ester
• CAS NO: 1439358-24-3
• Molecular Weight: 353.398
• Mol File: 1439358-24-3.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: (4-benzenesulfonylphenyl)carbamic acid phenyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: (4-benzenesulfonylphenyl)carbamic acid phenyl ester(1439358-24-3)
• EPA Substance Registry System: (4-benzenesulfonylphenyl)carbamic acid phenyl ester(1439358-24-3)

Safety Data

• Hazardous Substances Data: 1439358-24-3(Hazardous Substances Data)

Upstream product

• 1146-39-0 4-nitrophenyl phenyl sulfone 
• 7019-01-4 p-aminophenyl phenyl sulfone 
• 1885-14-9 phenyl chloroformate 
• 350-46-9 4-Fluoronitrobenzene 
• 873-55-2 sodium benzenesulfonate 

Downstream Products

• 54528-22-2 1-[4-(benzenesulfonyl)phenyl]-3-(pyridin-3-ylmethyl)urea 
• 1439357-88-6 C₂₀H₁₉N₃O₃S 
• 1439357-90-0 C₂₀H₁₉N₃O₃S 
• 1443137-39-0 1-[4-(benzenesulfonyl)phenyl]-3-{5H,6H,7H,8H-imidazo[1,2-a]pyridin-6-ylmethyl}urea 
• 1443137-42-5 3-[4-(benzenesulfonyl)phenyl]-1-methyl-1-(pyridin-3-ylmethyl)urea 
• 1439358-07-2 C₁₈H₁₇N₅O₃S 
• 1439358-06-1 C₁₈H₁₆N₄O₃S 
• 1439358-05-0 C₁₈H₁₆N₄O₃S 
• 1439358-04-9 C₁₈H₁₆N₄O₃S 
• 1439358-03-8 C₁₉H₁₆FN₃O₃S 
• 1363132-11-9 (1-((6-dimethylamino)pyridin-3-yl)methyl)-3-(4-(phenylsulfonyl)phenyl)urea 
• 1363130-82-8 1-[(6-aminopyridin-3-yl)methyl]-3-[4-(benzenesulfonyl)phenyl]urea 
• 1439358-02-7 C₁₉H₁₆ClN₃O₃S 
• 1439358-00-5 C₂₀H₁₉N₃O₄S 

Relevant articles and documents

SMALL MOLECULE ACTIVATORS OF NICOTINAMIDE PHOSPHORIBOSYLTRANSFERASE (NAMPT) AND USES THEREOF

Provided herein are small molecule activators of Nicotinamide Phosphoribosyltransferase (NAMPT), compositions comprising the compounds, and methods of using the compounds and compositions.

Structure-based identification of ureas as novel nicotinamide phosphoribosyltransferase (Nampt) inhibitors

Nicotinamide phosphoribosyltransferase (Nampt) is a promising anticancer target. Virtual screening identified a thiourea analogue, compound 5, as a novel highly potent Nampt inhibitor. Guided by the cocrystal structure of 5, SAR exploration revealed that the corresponding urea compound 7 exhibited similar potency with an improved solubility profile. These studies also indicated that a 3-pyridyl group was the preferred substituent at one inhibitor terminus and also identified a urea moiety as the optimal linker to the remainder of the inhibitor structure. Further SAR optimization of the other inhibitor terminus ultimately yielded compound 50 as a urea-containing Nampt inhibitor which exhibited excellent biochemical and cellular potency (enzyme IC50 = 0.007 μM; A2780 IC50 = 0.032 μM). Compound 50 also showed excellent in vivo antitumor efficacy when dosed orally in an A2780 ovarian tumor xenograft model (TGI of 97% was observed on day 17).