1439362-23-8

Basic information

• Product Name: tert-butyl 3-((naphthalen-1-ylmethyl)((4'-(((pyridin-2-ylmethyl)(pyridin-4-ylmethyl)amino)methyl)biphenyl-4-yl)methyl)amino)propylcarbamate
• CAS NO: 1439362-23-8
• Molecular Weight: 691.916
• Mol File: 1439362-23-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: tert-butyl 3-((naphthalen-1-ylmethyl)((4'-(((pyridin-2-ylmethyl)(pyridin-4-ylmethyl)amino)methyl)biphenyl-4-yl)methyl)amino)propylcarbamate(CAS DataBase Reference)
• NIST Chemistry Reference: tert-butyl 3-((naphthalen-1-ylmethyl)((4'-(((pyridin-2-ylmethyl)(pyridin-4-ylmethyl)amino)methyl)biphenyl-4-yl)methyl)amino)propylcarbamate(1439362-23-8)
• EPA Substance Registry System: tert-butyl 3-((naphthalen-1-ylmethyl)((4'-(((pyridin-2-ylmethyl)(pyridin-4-ylmethyl)amino)methyl)biphenyl-4-yl)methyl)amino)propylcarbamate(1439362-23-8)

Safety Data

• Hazardous Substances Data: 1439362-23-8(Hazardous Substances Data)

Upstream product

• 1022542-98-8 C₁₇H₁₄N₂O₄S 
• 39110-74-2 (α-naphthylmethyl)ammonium chloride 
• 86-53-3 1-Cyanonaphthalene 
• 24424-99-5 di-tert-butyl dicarbonate 
• 83948-53-2 3-bromopropylamine tert-butylcarbamate 
• 1216944-04-5 tert-butyl 3-(naphthalen-1-ylmethylamino)propylcarbamate 
• 1439361-95-1 tert-butyl 3-(N-(naphthalen-1-ylmethyl)-2-nitrophenylsulfonamido)propylcarbamate 
• 227018-14-6 (2-pyridylmethyl)(4-pyridylmethyl)amine 
• 1439362-14-7 tert-butyl 3-(((4'-(bromomethyl)biphenyl-4-yl)methyl)(naphthalen-1-ylmethyl)amino)propylcarbamate 
• 1439362-09-0 C₁₈H₁₆N₄O₄S 
• 117507-66-1 N-(2-nitrobenzenesulfonyl)-2-(aminomethyl)pyridine 
• 3731-51-9 2-(Aminomethyl)pyridine 

Relevant articles and documents

Low-Molecular-Weight CXCR4 Ligands with Variable Spacers

Low-molecular-weight CXCR4 ligands based on known lead compounds including the 14-mer peptide T140, the cyclic pentapeptide FC131, peptide mimetics, and dipicolylamine-containing compounds were designed and synthesized. Three types of aromatic spacers, 1,4-phenylenedimethanamine, naphthalene-2,6-diyldimethanamine, and [1,1′-biphenyl]-4,4′-diyldimethanamine, were used to build four pharmacophore groups. As pharmacophore groups, 2-pyridylmethyl and 1-naphthylmethyl are present in all of the compounds, and several aromatic groups and a cationic group from 1-propylguanidine and 1,1,3,3-tetramethyl-2-propylguanidine were also used. Several compounds showed significant CXCR4 binding affinity, and zinc(II) complexation of bis(pyridin-2-ylmethyl)amine moieties resulted in a remarkable increase in CXCR4 binding affinity.