1439377-39-5Relevant articles and documents
Preparation of aryl-substituted 2-oxyindoles by superelectrophilic chemistry
Naredla, Rajasekhar Reddy,Raja, Erum K.,Klumpp, Douglas A.
, p. 3245 - 3247 (2013/06/27)
A series of pyridyl-substituted 3-hydroxy-2-oxyindoles have been prepared and reacted with arenes in superacid promoted Friedel-Crafts reactions. The product aryl-substituted 2-oxyindoles are formed in generally good yields. With substituted arenes such as toluene, bromobenzene, or ethyl salicylate, the Friedel-Crafts reactions occur with excellent regioselectivity. A mechanism is proposed involving dicationic, superelectrophilic species leading to the electrophilic aromatic substitution chemistry.