99304-31-1

Basic information

• Product Name: 5-bromo-3-hydroxy-3-(2-pyridinylmethyl)-1,3-dihydro-2H-indol-2-one
• Synonyms: 5-bromo-3-hydroxy-3-(2-pyridinylmethyl)-1,3-dihydro-2H-indol-2-one
• CAS NO: 99304-31-1
• Molecular Formula: C14H11BrN2O2
• Molecular Weight: 319.15334
• Mol File: 99304-31-1.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 525.5°Cat760mmHg
• Flash Point: 271.6°C
• Appearance: /
• Density: 1.643g/cm³
• Vapor Pressure: 7.19E-12mmHg at 25°C
• Refractive Index: 1.684
• CAS DataBase Reference: 5-bromo-3-hydroxy-3-(2-pyridinylmethyl)-1,3-dihydro-2H-indol-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: 5-bromo-3-hydroxy-3-(2-pyridinylmethyl)-1,3-dihydro-2H-indol-2-one(99304-31-1)
• EPA Substance Registry System: 5-bromo-3-hydroxy-3-(2-pyridinylmethyl)-1,3-dihydro-2H-indol-2-one(99304-31-1)

Safety Data

• Hazardous Substances Data: 99304-31-1(Hazardous Substances Data)

Usage

InChI:InChI=1/C14H11BrN2O2/c15-9-4-5-12-11(7-9)14(19,13(18)17-12)8-10-3-1-2-6-16-10/h1-7,19H,8H2,(H,17,18)

Upstream product

• 109-06-8 α-picoline 
• 87-48-9 5-Bromo-1H-indole-2,3-dione 

Downstream Products

• 1439377-41-9 5-bromo-3-(4-methoxyphenyl)-3-(pyridin-2-ylmethyl)indolin-2-one 
• 1439377-40-8 ethyl 5-(5-bromo-2-oxo-3-(pyridin-2-ylmethyl)indolin-3-yl)-2-hydroxybenzoate 
• 1439377-39-5 5-bromo-3-(pyridin-2-ylmethyl)-3-(4-(3-(pyridin-4-yl)propyl)phenyl)indolin-2-one 
• 1439377-38-4 5-bromo-3-(4-hydroxy-3,5-dimethylphenyl)-3-(pyridin-2-ylmethyl)indolin-2-one 
• 1439377-37-3 5-bromo-3-(4-bromophenyl)-3-(pyridin-2-ylmethyl)indolin-2-one 
• 1439377-36-2 5-bromo-3-(pyridin-2-ylmethyl)-3-(p-tolyl)indolin-2-one 
• 1439377-35-1 5-bromo-3-phenyl-3-(pyridin-2-ylmethyl)indolin-2-one 

Relevant articles and documents

Polyethylene glycol (PEG-400): A mild and efficient reaction medium for one-pot synthesis of 3-hydroxy-3-(pyridin-2-ylmethyl)indolin-2-ones

3-(Pyridylmethyl)-3-hydroxy-2-oxindole derivatives were synthesized in high yields under mild, and catalyst-free conditions using polyethylene glycol (PEG-400) as a solvent. The use of low cost PEG-400 makes it simple, convenient, and environmentally beni

Microwave assisted catalyst-free synthesis of azaarene-substituted 3-hydroxy-2-oxindoles by the functionalization of sp3 C-H bond in methyl pyridine

A highly efficient synthesis of azaarene-substituted 3-hydroxy-2-oxindoles in catalyst-free conditions is described by the reaction of 2-methyl pyridines with isatins under microwave irradiation in aqueous medium. Simple reaction conditions, high yields o

Chemistry of indoles carrying a basic function, Part 3. Synthesis of spiro[cyclopropane-1,3'[3H]indol]-2'(1'H)-ones with antihypoxic effects

Hydroxyindolones (1-6, 15-16) were transformed into isatinylidenes (7,9-13, 17-19) by dehydration with 4-toluenesulfonic acid. The dimer-type compounds (14, 20) were also isolated in a few cases. The obtained isatinylidenes were transformed into 3-spiro-cyclopropane-oxindoles (21-32) with dimethyloxosulfonium methylide. Compound 22 shows protective effects against hypobaric hypoxia and triethyltin induced brain edema.