1439381-79-9

Upstream product

• 69739-34-0 t-butyldimethylsiyl triflate 
• 1439381-77-7 4,6-O-benzylidene-3-deoxy-2-O-(tert-butyldimethylsilyl)-3-C-ethenyl-α-D-altropyranoside 
• 3282-30-2 pivaloyl chloride 

Downstream Products

• 1439382-00-9 1α,25-dihydroxy-2α-[2-(2H-tetrazol-2-yl)ethyl]vitamin D₃ 
• 1439382-01-0 1α,25-dihydroxy-2α-[2-(1H-tetrazol-1-yl)ethyl]vitamin D₃ 
• 1439382-02-1 1α,25-dihydroxy-2α-[2-(1,2,4-triazol-2-yl)ethyl]vitamin D₃ 
• 1439382-03-2 1α,25-dihydroxy-2α-[2-(2H-1,2,3-triazol-2-yl)ethyl]vitamin D₃ 
• 1439382-04-3 1α,25-dihydroxy-2α-[2-(2H-1,2,3-triazol-1-yl)ethyl]vitamin D₃ 
• 1439382-05-4 1α,25-dihydroxy-2α-[2-(imidazole-1-yl)ethyl]vitamin D₃ 
• 1439381-94-8 C₄₈H₉₀N₄O₃Si₃ 
• 1439381-95-9 C₄₈H₉₀N₄O₃Si₃ 
• 1439381-96-0 C₄₉H₉₁N₃O₃Si₃ 
• 1439381-97-1 C₄₉H₉₁N₃O₃Si₃ 
• 1439381-98-2 C₄₉H₉₁N₃O₃Si₃ 
• 1439381-80-2 methyl 4-O-benzoyl-6-bromo-2-O-(tert-butyldimethylsilyl)-3,6-dideoxy-3-C-(2-pivaloyloxyethyl)-α-D-altropyranoside 
• 1439381-99-3 C₅₀H₉₂N₂O₃Si₃ 
• 1439381-81-3 (2S,3R,4R)-4-benzoyloxy-2-(tert-butyldimethylsilyl)oxy-3-(2-pivaloyloxyethyl)hex-5-en-1-ol 

Relevant academic research and scientific papers

Synthesis of 2α-heteroarylalkyl active vitamin D3 with therapeutic effect on enhancing bone mineral density in vivo

2α-Heteroarylethyl-1α,25-dihydroxyvitamin D3 analogues, which were designed to form a hydrogen bond between Arg274 of human vitamin D receptor (hVDR) and a nitrogen atom of the heteroaromatic ring at the 2α-position, were synthesized. Among them, 2α-[2-(tetrazol-2-yl) ethyl]-1α,25-dihydroxyvitamin D3 showed higher osteocalcin promoter transactivation activity in human osteosarcoma (HOS) cells and a greater therapeutic effect in ovariectomized (OVX) rats, osteoporosis model animals, on enhancing bone mineral density than those of active vitamin D 3. X-ray cocrystallographic analysis of the hVDR-ligand complex confirms that the new hydrogen bond formation stabilized the complex.