14394-77-5

Upstream product

• 105-56-6 ethyl 2-cyanoacetate 
• 877-79-2 4-(dimethylamino)-N-methylbenzylimine 
• 64-17-5 ethanol 
• 100-10-7 4-dimethylamino-benzaldehyde 
• 107-91-5 cyanoacetic acid amide 
• 2826-28-0 p-(N-dimethylamino benzylidene) malononitrile 
• 14447-18-8 benzyl 2-cyanoacetate 
• 1187-46-8 ethyl bromocyanoacetate 
• 154180-94-6 [1-(4-Dimethylamino-phenyl)-meth-(E)-ylidene]-(5-methyl-2H-pyrazol-3-yl)-amine 
• 62309-98-2 Chlormethylen-cyanessigsaeure-ethylester 
• 121-69-7 N,N-dimethyl-aniline 
• 889-37-2 N,N-dimethyl-4-((phenylimino)methyl)aniline 
• 57806-78-7 p-dimethylamino-1-(dichloromethyl)benzene 

Downstream Products

• 556-18-3 4-aminobenzaldehyde 
• 727973-54-8 6-{[(4-dimethylamino)phenyl]methylidene}-6,11-dihydro-13H-isoquino[3,2-b]quinazolin-13-one 
• 857814-57-4 2-aminomethyl-3-(4-dimethylamino-phenyl)-propionic acid 
• 1253932-68-1 ethyl 2-amino-8-chloro-4-(4-N,N-dimethylaminophenyl)-4H-pyrimido[2,1-b][1,3]benzothiazole-3-carboxylate 
• 1886-53-9 N-Cyclohexyl-(4-dimethylamino-benzal)-cyanacetamid 
• 112906-24-8 2-[(Z)-3-(4-Dimethylamino-phenyl)-1-thiophen-2-yl-allylidene]-malononitrile 
• 1263308-21-9 2-amino-5-cyano-4-(4-dimethylaminophenyl)-6-oxo-1-{1-[4-(piperidine-1-sulfonyl)phenyl]ethylideneamino}-1,6-dihydropyridine-3-carboxylic acid ethyl ester 

Relevant academic research and scientific papers

First report of the application of simple molecular complexes as organo-catalysts for Knoevenagel condensation

A series of molecular complexes have been designed, synthesized and used as organo-catalysts for the first time for very efficient Knoevenagel condensation. Molecular complexes are thermally stable, easily recyclable, and have a low cost of preparation. T

Synthesis of Pyrazoloisoquinoline and Pyrazolopyridine Derivatives from Azomethines and CH-Acidic Compounds

Donor substituted arylidene aminopyrazoles 1a-c and CH-acidic 1,3-dicarbonyl compounds 2a-e give in ethanol in an addition / cyclization reaction pyrazoloisoquinolines 4a-i and pyrazolopyridine derivatives 5a,b, respectively.Using ethyl cyanoacetate as CH-acidic component, cinnamate 6 and the cyano substituted pyrazolopyridine 7 are formed. - Keywords.Azomethine; CH-Acidic compound; Addition / cyclization reaction.

Reactivity of Nitroalkyl Anions Addition to Substituted Benzylidenecyanoacetates: Electrophilicity Parameters and Free Energy Relationships

The kinetics of the reactions of benzylidenecyanoacetates 1a–d (X = H, Me, OMe, and NMe2) with nitroalkyl anions 2a–c have been studied in aqueous solution at 20°C. The second-order rate constants are used to evaluate the electrophilicity param

Efficient knoevenagel condensation catalyzed by 2-hydroxyethylammonium acetate under solvent-free conditions at room temperature

An efficient method for Knoevenagel condensation of aromatic aldehydes with malononitrile or ethyl cyanoacetate has been developed using the inexpensive and environmentally friendly ionic liquid 2-hydroxyethylammonium acetate as catalyst. The reactions we

Polycarbosilane-supported titanium(IV) catalyst for Knoevenagel condensation reaction

Polycarbosilane (PCS) was synthesized by the polycondensation of trichloromethylsilane and trimethoxyvinylsilane in the presence of sodium metal. PCS has a highly crosslinked structure, high ceramic yield and high surface area. Titanium metal ion was attached to the polycarbosilane and its catalytic activity was investigated. The Knoevenagel condensation reaction catalysed by titanium-incorporated polycarbosilane is reported. The titanium-incorporated PCS catalysed the reaction well and with a diverse set of substrates the reaction proceeded with good yield. PCS-supported transition metal catalysts have been prepared for the first time and used successfully in the Knoevenagel condensation reaction. Copyright

Peculiarities of 2-amino-3-R-4-aryl-4H-pyranes multicomponent synthesis derived from 1H-2,1-benzothiazin-4(3H)-one 2,2-dioxide

The new 2-amino-3-R-4-aryl-6-ethyl-4,6-dihydropyrano[3,2-c][2,1]benzothiazine 5,5-dioxides were synthesized via three-component interaction of 1H-2,1-benzothiazin-4(3H)-one 2,2-dioxide with arylcarbaldehydes and active methylene nitriles. Depending on the

Leucoemeraldine-Base-Catalyzed Knoevenagel Condensation

A facile method for Knoevenagel condensation has been developed by using Leucoemeraldine base as catalyst to give substituted alkenes in excellent yields. The recycling of the solid catalyst was investigated.

Highly stable naphthalene core based novel cleft-shaped strain molecule: Influence of intermolecular H-bonding architectures

The significance of intermolecular classical and non-classical H-bonding interactions in the stabilization of a naphthalene core based conformationally rigid cleft-shaped 1,5-dioxocin (BNAP) is presented here. The importance of H-bonding interactions to a

Knoevenagel condensation of aldehydes with active methylene compounds catalyzed by MgC2O4/SiO2 under microwave irradiation and solvent-free conditions

MgC2O4/SiO2 catalyzes the efficient Knoevenagel condensation of aldehydes with active methylene compounds in solvent-free conditions under microwave irradiation to give alkenes derivatives in excellent yields. MgC2/s

Ionic liquids as solvents for the Knoevenagel condensation: Understanding the role of solvent-solute interactions

The Knoevenagel condensation in ionic liquids has been demonstrated as a strongly solvent-dependent process. The objective of this study was to establish a simple and descriptive trend of solvent-solute interactions that favour the Knoevenagel condensatio