143945-72-6

Basic information

• Product Name: 5-(2-Bromophenyl)-1-(triphenylmethyl)-1H-tetrazole
• Synonyms: N-(Triphenylmethyl)-5-(2-bromophenyl)-1H-tetrazole;5-(2-Bromophenyl)-1-(triphenylmethyl)-1H-tetrazole
• CAS NO: 143945-72-6
• Molecular Formula: C₂₆H₁₉BrN₄
• Molecular Weight: 467.36
• Product Categories: API intermediates
• Mol File: 143945-72-6.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 623.249 °C at 760 mmHg
• Flash Point: 330.729 °C
• Appearance: /
• Density: 1.33
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.668
• PKA: 0.16±0.10(Predicted)
• CAS DataBase Reference: 5-(2-Bromophenyl)-1-(triphenylmethyl)-1H-tetrazole(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(2-Bromophenyl)-1-(triphenylmethyl)-1H-tetrazole(143945-72-6)
• EPA Substance Registry System: 5-(2-Bromophenyl)-1-(triphenylmethyl)-1H-tetrazole(143945-72-6)

Safety Data

• Hazardous Substances Data: 143945-72-6(Hazardous Substances Data)

Usage

General Description

5-(2-Bromophenyl)-1-(triphenylmethyl)-1H-tetrazole is a chemical compound with the molecular formula C25H20BrN5. It is a tetrazole derivative with a unique structure that consists of a tetrazole ring attached to a phenyl and a triphenylmethyl group. 5-(2-Bromophenyl)-1-(triphenylmethyl)-1H-tetrazole has potential applications in medicinal chemistry and pharmaceutical research. It may have biological activities and could be used as a building block for the synthesis of other compounds with diverse properties. Additionally, its structural complexity makes it an interesting target for synthetic and computational studies in the field of organic chemistry.

InChI:InChI=1/C26H19BrN4/c27-24-19-11-10-18-23(24)25-28-29-30-31(25)26(20-12-4-1-5-13-20,21-14-6-2-7-15-21)22-16-8-3-9-17-22/h1-19H

Upstream product

• 73096-42-1 5-(2-bromophenyl)-1H-tetrazole 
• 76-83-5 trityl chloride 
• 123-91-1 1,4-dioxane 

Downstream Products

• 138402-10-5 trityl irbesartan 
• 124751-00-4 2-Butyl-4-chloro-1-[[2'-[1-(triphenylmethyl)-1H-tetrazol-5-yl][1,1'-biphenyl]-4-yl]methyl]-1H-imidazole-5-methanol 
• 120568-18-5 2-Butyl-4-chloro-1-[[2'-[1-(triphenylmethyl)-1H-tetrazol-5-yl][1,1'-biphenyl]-4-yl]methyl]-1H-imidazole-5-carboxaldehyde 
• 137862-53-4 N-pentanoyl-N-[[2'-(1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl]-methyl]-(L)-valine 
• 781664-81-1 N-[[2'-(1-triphenylmethyltetrazol-5yl)biphenyl-4-yl]methyl]-N-valeryl-L-valine methyl ester 
• 894793-42-1 tert-butyl N-pentanoyl-N-[{2'-[1-(triphenylmethyl)-1H-tetrazol-5-yl]-1,1'-biphenyl-4-yl}methyl]-L-valinate 
• 137864-44-9 N-[(2'-(1-triphenylmethyl-tetrazol-5-yl)biphenyl-4-yl)methyl]-N-valeroyl-(L)-valine benzyl ester 
• 141887-45-8 ethyl 2-biphenyl-4-yl)-methyl>amino>pyridine-3-carboxylate 

Relevant articles and documents

INTERMEDIATE COMPOUNDS FOR THE PREPARATION OF ANGIOTENSIN II RECEPTOR ANTAGONISTS

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5-aryleheteroarylalkyl-1,3,5-trisubstituted-1,2,4-triazole compounds for treatment of circulatory disorders

A class of 5-arylheteroarylalkyl-1,3,5-trisubstituted-1,2,4-triazole compounds is described for use in treatment of circulatory disorders such as hypertension. Compounds of particular interest are angiotensin II antagonists of the formula wherein A is selected from wherein m is one; wherein R1 is selected from ethyl, n-propyl, isopropyl, n-butyl, sec-butyl, isobutyl, tert-butyl, 4-methylbutyl, n-pentyl, neopentyl, benzyl, cyclohexyl, cyclohexylmethyl, 2-butenyl, 3-butenyl, 2-butynyl, 3-butynyl and 2-hydroxybutyl; wherein R2 is selected from ethyl, n-propyl, isopropyl, n-butyl, sec-butyl, isobutyl, 4-methylbutyl, tert-butyl, n-pentyl, neo-pentyl, 1-oxoethyl, 1-oxopropyl, 1-oxobutyl, 1-oxopentyl, 1,1-dimethoxypropyl, 1,1-dimethoxypentyl, halo, difluoromethyl, 1-oxo-2-phenylethyl, 1-oxo-2-cyclohexylethyl, 1,1-difluoro-2-phenylethyl, 1,1-difluoro-2-cyclohexylethyl, 2-cyclohexylethyl, 1,1-difluoro-3-cyclohexylpropyl, 1,1-dimethoxybutyl, 1,1-difluoroethyl, 1,1-difluoropropyl, 1,1-difluorobutyl, 1,1-difluoropentyl, benzyl, 2-phenylethyl, 1,1-difluoro-3-phenylpropyl, cyclohexylmethyl, cyclohexanoyl, 1-butenyl, 2-butenyl, 3-butenyl, 1-butynyl, 2-butynyl, 3-butynyl, propylthio and butylthio; wherein each of R3, R4, R6 through R11 is hydrido and R5 is selected from COOH, SH, PO3H2, SO3H, CONHNH2, CONHNHSO2CF3, OH, wherein each of R42 and R43 is independently selected from chloro, cyano, nitro, trifluoromethyl, methoxycarbonyl and trifluoromethylsulfonyl.

A novel and expeditious route to A-81988: An angiotensin II receptor antagonist

A novel and efficient synthesis of A-81988, an angiotensin II receptor antagonist, is described. The key step utilizes a palladium-catalyzed biaryl coupling between a phenylboronic acid derivative and N-trityl-5-(2-bromophenyl)tetrazole.