143947-37-9

Basic information

• Product Name: Propanamide, N,N'-[5-(4-chlorophenyl)-6-ethyl-2,4-pyrimidinediyl]bis-
• CAS NO: 143947-37-9
• Molecular Formula: C18H21ClN4O2
• Molecular Weight: 360.843
• Mol File: 143947-37-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: Propanamide, N,N'-[5-(4-chlorophenyl)-6-ethyl-2,4-pyrimidinediyl]bis-(CAS DataBase Reference)
• NIST Chemistry Reference: Propanamide, N,N'-[5-(4-chlorophenyl)-6-ethyl-2,4-pyrimidinediyl]bis-(143947-37-9)
• EPA Substance Registry System: Propanamide, N,N'-[5-(4-chlorophenyl)-6-ethyl-2,4-pyrimidinediyl]bis-(143947-37-9)

Safety Data

• Hazardous Substances Data: 143947-37-9(Hazardous Substances Data)

Upstream product

• 143947-41-5 C₂₆H₂₁ClN₄O₂ 
• 143947-40-4 N-[5-(4-Chloro-phenyl)-2-(2,2-dimethyl-propionylamino)-6-ethyl-pyrimidin-4-yl]-2,2-dimethyl-propionamide 
• 71523-78-9 Diacetamidopyrimethamine 
• 58-14-0 2,4-diamino-5-(4-chlorophenyl)-6-ethylpyrimidine 
• 123-62-6 propionic acid anhydride 

Downstream Products

• 143947-42-6 N-[4-Amino-5-(4-chloro-phenyl)-6-ethyl-pyrimidin-2-yl]-propionamide 

Relevant articles and documents

Regioselective Deacylation of 2,4-Diacylaminopyrimidine Derivatives by Lewis Acids and Crystal Structures of Two Products

Deacylation of 2,4-diacylamino derivatives of pyrimethamine and related diaminopyrimidines with tin(II) chloride or zinc chloride, in ethanol or propan-2-ol, affords 2-acyl-4-aminopyrimidines exclusively.Regioselective 4-deacylation was observed by 1H NMR spectroscopy and established by crystallographic analysis of the 2,4-dipropionylpyrimidine 11 and the corresponding 4-amino-2-propionylpyrimidine deacylation product 17.The latter exists in the solid state as an unusual base-pair dimer linked by two pairs of equivalent hydrogen bonds.