1439552-58-5

Upstream product

• 766-97-2 4-n-methylphenylacetylene 
• 3848-36-0 4-chlorobenzaldoxime 
• 14688-31-4 3-(4′-chlorophenyl)-5-(4′′-methylphenyl)isoxazole 
• 104-87-0 4-methyl-benzaldehyde 
• 132589-36-7 1-(4-methylphenyl)prop-2-yn-1-ol 
• 14377-18-5 1-(4-methylphenyl)prop-2-yn-1-one 
• 76862-09-4 methyl N-(4-chlorobenzylidene)glycinate 

Relevant academic research and scientific papers

Catalyst control in positional-selective C-H alkenylation of isoxazoles and a ruthenium-mediated assembly of trisubstituted pyrroles

High levels of catalyst control are demonstrated in determining the positional selectivity in C-H alkenylation of isoxazoles. A cationic rhodium-mediated, strong-directing group promotes C(sp2)-H activation at the proximal aryl ring whereas, the palladium-mediated electrophilic metallation leads to the C(sp2)-H activation at the distal position of the directing group. Synthetic elaboration of this C-H alkenylation product via ruthenium and copper co-catalysis leads to an efficient method for the assembly of densely substituted pyrroles.

Direct synthesis of pyrroles via 1,3-dipolar cycloaddition of azomethine ylides with ynones

A direct and facile synthesis of multi-substituted pyrroles via AgOAc-catalyzed 1,3-dipolar cycloaddition of azomethine ylides with ynones is developed, providing the corresponding adducts in moderate to high yields (up to 89%).