143969-10-2

Usage

Structure

A pyridinone derivative featuring a 4-methylphenyl and a phenyl group

Usage

Building block in organic synthesis and medicinal chemistry

Pharmacological activity

Potential in the area of neuroprotection and inflammation modulation

Value

Unique structure and properties make it a valuable tool for the development of new pharmaceutical compounds and research in drug design and discovery.

Upstream product

• 25631-82-7 4-phenyl-2H-pyran-2,6(3H)-dione 
• 1004-22-4 (phenylethynyl)sodium 
• 38477-35-9 2-oxo-4-phenyl-6-p-tolyl-1,2,3,4-tetrahydro-pyridine-3-carbonitrile 
• 25855-99-6 1-(4-methylphenyl)-3-phenyl-1,3-propanedione 
• 20442-65-3 1-(4-methylphenyl)-3-phenylprop-2-yn-1-one 
• 38468-92-7 2-hydroxy-4-phenyl-6-p-tolyl-nicotinonitrile 

Relevant academic research and scientific papers

Three-Component Castagnoli-Cushman Reaction of 3-Arylglutaconic Acid Anhydrides, Carbonyl Compounds, and Ammonium Acetate: a Quick and Flexible Way to Assemble Polysubstituted NH-δ-lactams

A practical straightforward synthesis of medicinally important NH-δ-lactams through the three-component Castagnoli-Cushman reaction of 3-arylglutaconic anhydrides with carbonyl compound and ammonium acetate has been developed. The scope of the protocol has been thoroughly explored paying particular attention to the carbonyl component using wide array of aliphatic and aromatic aldehydes as well as rarely involved cyclic and acyclic ketones. Synthetic potential of prepared compounds was demonstrated by a series of post-modifications, including unexpected isomerization.