20442-65-3

Upstream product

• 591-50-4 iodobenzene 
• 14377-18-5 1-(4-methylphenyl)prop-2-yn-1-one 
• 14271-73-9 4-methylbenzoyl cyanide 
• 536-74-3 phenylacetylene 
• 874-60-2 4-methyl-benzoyl chloride 
• 2170-06-1 1-Phenyl-2-(trimethylsilyl)acetylene 
• 201230-82-2 carbon monoxide 
• 624-31-7 4-tolyl iodide 
• 32584-71-7 diphenyl(phenylethynyl)stibine 
• 4294-57-9 para-methylphenylmagnesium bromide 
• 647833-19-0 1-(1H-benzo[d]-[1,2,3]triazol-1-yl)-3-phenylprop-2-yn-1-one 
• 951025-63-1 N-[1-(4-methylphenyl)-3-phenylprop-2-yn-1-ylidene]propyl-2-amine 
• 29540-83-8 p-tolyl triflate 
• 13984-49-1 (phenylethynyl)zinc chloride 

Downstream Products

• 856344-29-1 ethyl 2-oxo-4-phenyl-6-(p-tolyl)-2H-pyran-3-carboxylate 
• 86175-40-8 (Z)-3-(4-Methoxy-phenylsulfanyl)-3-phenyl-1-p-tolyl-propenone 
• 86175-44-2 (Z)-3-(4-Nitro-phenylsulfanyl)-3-phenyl-1-p-tolyl-propenone 
• 66870-43-7 1-methyl-5-(4-methylphenyl)-3-phenyl-1H-pyrazole 
• 56119-90-5 1-methyl-3-(4'-methylphenyl)-5-phenyl-1H-pyrazole 
• 882182-79-8 (3,3-difluoro-2-phenyl-cycloprop-1-enyl)-p-tolyl-methanone 
• 936924-39-9 C₁₉H₁₉NO₂Te 
• 1042682-59-6 (E)-4-fluoro-3-phenyl-4,4-bis(phenylsulfonyl)-1-(p-tolyl)but-2-en-1-one 
• 1042682-75-6 2-[2-fluoro-1-phenyl-2-(phenylsulfonyl)ethylidene]-1-phenyl-3-(p-tolyl)propane-1,3-dione 
• 1261271-15-1 ethyl 3-acetyl-1-methyl-5-(4-methylbenzoyl)-6-phenyl-1,2,3,4-tetrahydropyridine-3-carboxylate 
• 1261270-93-2 1,1'-(1-ethyl-5-(4-methylbenzoyl)-6-phenyl-1,2,3,4-tetrahydropyridine-3,3-diyl)diethanone 
• 1261270-99-8 1-ethyl-5-(4-methylbenzoyl)-6-phenyl-1,2-dihydropyridine-3,3(4H)-dicarbonitrile 
• 1261270-91-0 1,1'-(1-methyl-5-(4-methylbenzoyl)-6-phenyl-1,2,3,4-tetrahydropyridine-3,3-diyl)diethanone 
• 1261270-97-6 1-methyl-5-(4-methylbenzoyl)-6-phenyl-1,2-dihydropyridine-3,3(4H)-dicarbonitrile 

Relevant academic research and scientific papers

Flexible Construction of Functionalized-Pyrroles under Palladium or Copper Catalysis in the Presence of BF3 ? Et2O

We have developed a flexible approach enabling the access to highly functionalized pyrroles under palladium or copper catalysis in the presence of BF3 ? Et2O. This catalytic methodology utilizes commercially available amines as react

Organoborane-catalyzed selective 1,2-reduction of alkynones with hydride transfer: Synthesis of benzyl alkynes

Benzyl alkynes are important organic building blocks in organic synthesis. We report herein a B(C6F5)3-catalyzed site-selective 1,2-reduction of readily available alkynones to access benzyl alkyne derivatives. Under the de

Atom-Economic Synthesis of Highly Functionalized Bridged Ring Systems Initiated by Ring Expansion of Indene-1,3-dione

An atom economic procedure for the regioselective synthesis of bridged seven-membered-ring compounds from simple reactants such as ynones and indene-1,3-dione has been developed. This process was realized through the one-pot reactions of ring-expansion of

Straightforward Stereoselective Synthesis of Seven-Membered Oxa-Bridged Rings through in Situ Generated Cycloheptenol Derivatives

An iodine-mediated stereoselective synthesis of seven-membered oxa-bridged rings via in situ generated cycloheptenols was reported. This process was realized through the combination of C-C σ-bond cleavage and C-O bond-forming reactions in a one-pot fashion from simple and easily accessible raw materials. The formation of carbon radicals initiated by I2 was the key to the reaction.

Ynonylation of Acyl Radicals by Electroinduced Homolysis of 4-Acyl-1,4-dihydropyridines

Herein we report the conversion of 4-Acyl-1,4-dihydropyridines (DHPs) into ynones under electrochemical conditions. The reaction proceeds via the homolysis of acyl-DHP under electron activation. The resulting acyl radicals react with hypervalent iodine(III) reagents to form the target ynones or ynamides in acceptable yields. This mild reaction condition allows wider functionality tolerance that includes halides, carboxylates, or alkenes. The synthetic utility of this methodology is further demonstrated by the late-stage modification of complex molecules.

Nickel (II) dibenzotetramethyltetraaza[14]annulene supported on DFNS nanoparticles catalyst in carbonylative sonogashira coupling

In this study, the carbonylative sonogashira coupling reaction was performed in the presence of CO (2 MPa) and Nitmtaa?DFNS as NPs. Nickel(II)dibenzotetramethyltetraaza[14]annulene complex (Nitmtaa) prepared and immobilized on amino-fucntionnalized DFNS (N-DFNS) via Ni[sbnd]N (NH2) bond to obtain a stable and reusable new nanocatalyst named as Nitmtaa?DFNS. Good to superb performance products were provided deploying Nitmtaa?DFNS nanocatalyst. In addition, the anatomy of Nitmtaa?DFNS has been distinguished by various methods, including XRD, VSM, FT-IR, SEM, EDX, TEM, and TGA. In addition, the hot filtration test provided complete insight into the heterogeneity of the catalyst. The reuse and recycling of the catalyst were repeatedly investigated for coupling reactions. In addition, the mechanism of the coupling reactions was thoroughly studied.

Sc(OTf)3-catalyzed [3 + 2]-cycloaddition of nitrones with ynones

An efficient approach to access functionalized (2,3-dihydroisoxazol-4-yl) ketones has been developed by reacting nitrones 4 with ynones 7 or terminal ynones 10 in a one-pot fashion. The reaction went through a formal Sc(OTf)3-catalyzed [3 + 2]-cycloaddition process to generate a number of functionalized (2,3-dihydroisoxazol-4-yl) ketones 11aa-11aw, 11ba-11la and 12aa-12ae in moderate to good yields. This journal is

Synthesis of Isoselenazoles and Isothiazoles from Demethoxylative Cycloaddition of Alkynyl Oxime Ethers

A general method for the synthesis of isoselenazoles and isothiazoles has been developed by the base-promoted demethoxylative cycloaddition of alkynyl oxime ethers using the cheap and inactive Se powder and Na2S as selenium and sulfur sources. This transformation features the direct construction of N-, Se-, and S-containing heterocycles through the formation of N-Se/S and C-Se/S bonds in one-pot reactions with excellent functional group tolerance.

Base-Promoted Synthesis of Polysubstituted 4-Aminoquinolines from Ynones and 2-Aminobenzonitriles under Transition-Metal-Free Conditions

A transition-metal-free and base-promoted one-pot reaction of ynones with 2-aminobenzonitriles is described. The reaction was initiated through sequential aza-Michael addition/intramolecular annulation to afford various multisubstituted 4-aminoquinolines

Synthesis of 2-isoxazolyl-2,3-dihydrobenzofuransviapalladium-catalyzed cascade cyclization of alkenyl ethers

A novel palladium-catalyzed cascade cyclization reaction of alkenyl ethers with alkynyl oxime ethers for the construction of poly-heterocyclic scaffolds has been developed, in which the electron-rich alkene moiety functions as a three-atom unit, simultaneously dealing well with the coordination and regioselectivity of electron-rich olefins under metal catalysis. The strategy features excellent regio- and chemoselectivities as well as good functional group tolerance. Moreover, the newly formed 2-isoxazolyl-2,3-dihydrobenzofuran products can be further transformed to diverse complex heterocycles, demonstrating their potential applications in organic synthesis and medicinal chemistry.