38468-92-7

Upstream product

• 38477-35-9 2-oxo-4-phenyl-6-p-tolyl-1,2,3,4-tetrahydro-pyridine-3-carbonitrile 
• 2025-40-3 ethyl benzylidenecyanoacetate 
• 122-00-9 para-methylacetophenone 
• 4224-96-8 3-phenyl-1-p-tolylprop-2-en-1-one 
• 107-91-5 cyanoacetic acid amide 
• 1004-22-4 (phenylethynyl)sodium 
• 25855-99-6 1-(4-methylphenyl)-3-phenyl-1,3-propanedione 
• 20442-65-3 1-(4-methylphenyl)-3-phenylprop-2-yn-1-one 

Downstream Products

• 143969-10-2 4-phenyl-6-(p-tolyl)-1,2-dihydropyridin-2-ol 

Relevant academic research and scientific papers

A simple and convenient synthesis of 4,6-disubstituted 3-cyanopyridin-2(1H)-ones under solvent-free microwave conditions

A rapid and efficient method for the preparation of 4,6-disubstituted 3-cyanopyridin-2(1H)-ones by the reaction between 1,3-diarylpropen-1-ones and cyanoacetamide using powdered potassium hydroxide under microwave irradiation is reported. Excellent yields and higher purity are obtained in this solvent free one pot synthesis as compared to conventional methods.

Synthesis of N-glycosylated pyridines as new antiviral agents

A series of 3-cyanopyridine glycosides have been synthesized and evaluated for their inhibitory activity against human immunodeficiency virus (HIV) replication in MT-4 cells. Among the 3-cyanopyridine glycosides 6-(p- methylphenyl) and 6-(p-aminophenyl) were the most selective inhibitors of HIV replication.