143995-55-5

Basic information

• Product Name: N-METHOXYCARBONYL-2-METHOXY-DL-GLYCINE METHYL ESTER
• Synonyms: N-METHOXYCARBONYL-2-METHOXY-DL-GLYCINE METHYL ESTER;methyl 2-methoxy-2-(methoxycarbonylamino)acetate
• CAS NO: 143995-55-5
• Molecular Formula: C₆H₁₁NO₅
• Molecular Weight: 177.16
• Mol File: 143995-55-5.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 285.6°C at 760 mmHg
• Flash Point: 126.5°C
• Appearance: /
• Density: 1.18g/cm³
• Vapor Pressure: 0.00278mmHg at 25°C
• Refractive Index: 1.428
• PKA: 9.62±0.46(Predicted)
• CAS DataBase Reference: N-METHOXYCARBONYL-2-METHOXY-DL-GLYCINE METHYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: N-METHOXYCARBONYL-2-METHOXY-DL-GLYCINE METHYL ESTER(143995-55-5)
• EPA Substance Registry System: N-METHOXYCARBONYL-2-METHOXY-DL-GLYCINE METHYL ESTER(143995-55-5)

Safety Data

• Hazardous Substances Data: 143995-55-5(Hazardous Substances Data)

Usage

InChI:InChI=1/C6H11NO5/c1-10-4(5(8)11-2)7-6(9)12-3/h4H,1-3H3,(H,7,9)

Upstream product

• 67-56-1 methanol 
• 64356-71-4 methyl 2-hydroxy-2-(methoxycarbonylamino)acetate 
• 56674-26-1 Hydroxy-methoxycarbonylamino-acetic acid 

Downstream Products

• 944718-26-7 (R)-2-Methoxycarbonylamino-2-(6-methoxy-1-oxo-1,3-dihydro-isoindol-2-ylmethyl)-4-(4-sulfo-phenyl)-but-3-ynoic acid methyl ester 
• 944718-25-6 (R)-2-Methoxycarbonylamino-2-(6-methoxy-1-oxo-1,3-dihydro-isoindol-2-ylmethyl)-4-(7-methyl-3H-imidazo[4,5-b]pyridin-6-yl)-but-3-ynoic acid methyl ester 
• 151312-38-8 methyl N-moc-α-methoxyglycyl-R,S-phenylglycinate 
• 149287-49-0 (4R*)-Methyl 4-(benzyloxy)-2--5-methyl-(2Z)-hexenoate 
• 149287-50-3 (4R*)-Methyl 4-(benzyloxy)-2--5-methyl-(2E)-hexenoate 
• 149287-56-9 (3S,4S)-Methyl 4-(benzyloxy)-3-bromo-2-pentanoate 
• 149287-46-7 (4S)-Methyl 4-(benzyloxy)-2--(2Z)-pentenoate 
• 149287-47-8 (4S)-Methyl 4-(benzyloxy)-2--(2E)-pentenoate 
• 143995-57-7 2-Methoxy-2-(methoxycarbonylamino)-N,N-dimethylacetamide 
• 145275-67-8 2-((Methoxycarbonyl)amino)-2-methoxyacetamide 
• 126369-62-8 (E)-2-Methoxycarbonylamino-5-phenyl-3-vinyl-pent-4-enoic acid methyl ester 
• 75806-14-3 methyl 1-<(trimethylsilyl)ethynyl>-N-carbomethoxyglycinate 
• 143995-58-8 N-Benzyl-2-methoxy-2-(methoxycarbonylamino)acetamide 

Relevant articles and documents

Synthesis of a naturally occurring diene-containing amino acid and its glutamyl dipeptide via N-acyliminium ion chemistry

The syntheses of the naturally occurring unusual unsaturated amino acid (S)-2-amino-3-methylene-4-pentenoic acid and the corresponding γ-glutamyl dipeptide are described. Key steps are an N-acyliminium ion addition using allenylmethylsilane as nucleophile and an enzymatic resolution mediated by the L-aminopeptidase from Pseudomonas putida. Wiley-VCH Verlag GmbH & Co. KGaA, 2008.

A photocaged, cyclopropene-containing analog of the amino acid neurotransmitter glutamate

Substituted cyclopropenes serve as compact biorthogonal appendages that enable analysis of biomolecules in complex systems. Neurotransmitters, a chemically diverse group of biomolecules that control neuron excitation and inhibition, are not among the systems that have been studied using biorthogonal chemistry. Here we describe the synthesis of cyclopropene-containing analogs of the excitatory amino acid neurotransmitter glutamate starting from a Garner's aldehyde-derived alkyne. The deprotected cyclopropene glutamate was stable in solution but decomposed upon concentration. Appending a light-cleavable group improved the stability of the cyclopropene while simultaneously caging the neurotransmitter. This strategy has the potential to permit deployment of cyclopropene-modified glutamate as a bioorthogonal probe of the neurotransmitter glutamate in vivo with spatiotemporal precision.

HYDANTOIN DERIVATIVES FOR THE TREATMENT OF INFLAMMATORY DISORDERS

This invention relates to compounds of the Formula: (I); or a pharmaceutically acceptable salt, solvate or isomer thereof, which can be useful for the treatment of diseases or conditions mediated by MMPs, ADAMs, TACE, aggrecanase, TNF-α or combinations thereof.