Methyl methoxy[(methoxycarbonyl)amino]acetate

Base Information

• Chemical Name: Methyl methoxy[(methoxycarbonyl)amino]acetate
• CAS No.: 143995-55-5
• Molecular Formula: C₆H₁₁NO₅
• Molecular Weight: 177.157
• DSSTox Substance ID: DTXSID80492661
• Mol file: 143995-55-5.mol

Synonyms:143995-55-5;N-Methoxycarbonyl-2-methoxy-DL-glycine methyl ester;Methyl methoxy[(methoxycarbonyl)amino]acetate;methyl 2-methoxy-2-(methoxycarbonylamino)acetate;SCHEMBL5956285;DTXSID80492661;AKOS006328614;FT-0765614;Methyl 2-methoxy-2-((methoxycarbonyl)amino)acetate;N-METHOXYCARBONYL-2-METHOXY-DL-GLYCINEMETHYLESTER

Chemical Property of Methyl methoxy[(methoxycarbonyl)amino]acetate

Chemical Property:

• Vapor Pressure: 0.00278mmHg at 25°C
• Refractive Index: 1.428
• Boiling Point: 285.6°C at 760 mmHg
• PKA: 9.62±0.46(Predicted)
• Flash Point: 126.5°C
• PSA: 73.86000
• Density: 1.18g/cm³
• LogP: -0.12120
• XLogP3: -0.1
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 5
• Exact Mass: 177.06372245
• Heavy Atom Count: 12
• Complexity: 169

Purity/Quality:

98%Min ^*data from raw suppliers

METHOXY-METHOXYCARBONYLAMINO-ACETIC ACID METHYL ESTER 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC(C(=O)OC)NC(=O)OC

Technology Process of Methyl methoxy[(methoxycarbonyl)amino]acetate

There total 2 articles about Methyl methoxy[(methoxycarbonyl)amino]acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

methanol (67-56-1) + Hydroxy-methoxycarbonylamino-acetic acid (56674-26-1) → 2--2-methoxyethanoate (143995-55-5)

Guidance literature:

sulfuric acid; Cooling with ice;

Reference yield:

methanol (67-56-1) + methyl 2-hydroxy-2-(methoxycarbonylamino)acetate (64356-71-4) → 2--2-methoxyethanoate (143995-55-5)

Guidance literature:

With sulfuric acid; trimethyl orthoformate; at 20 ℃; for 15h; Inert atmosphere;

DOI:10.1002/ejoc.200701016

Reference yield: 86.0%

2--2-methoxyethanoate (143995-55-5) + dimethyl amine (124-40-3) → 2-Methoxy-2-(methoxycarbonylamino)-N,N-dimethylacetamide (143995-57-7)

Guidance literature:

sodium cyanide; In methanol; for 1h; 0 deg C to room temp.;

DOI:10.1002/recl.19921110705

upstream raw materials:

methanol

Hydroxy-methoxycarbonylamino-acetic acid

methyl 2-hydroxy-2-(methoxycarbonylamino)acetate

Downstream raw materials:

(E)-2-Methoxycarbonylamino-5-phenyl-3-vinyl-pent-4-enoic acid methyl ester

2-((Methoxycarbonyl)amino)-2-methoxyacetamide

2-Methoxy-2-(methoxycarbonylamino)-N,N-dimethylacetamide

N-Benzyl-2-methoxy-2-(methoxycarbonylamino)acetamide