144-75-2 Usage
Originator
Diasone Sodium,Abbott,US,1947
Uses
Sodium Sulfoxone is used in tuberculosis therapy along with Streptomycin (S687500).
Manufacturing Process
About 20 grams of diamino diphenyl sulfone is dissolved in about 500 cc of
ethyl alcohol (3A made up of 5 parts methyl alcohol and 100 parts of ethyl
alcohol) by placing the ingredients in a flask provided with a reflux condenser
and warming over a water bath. About 24 grams of pure grade, very finely
powdered (40 to 60 mesh) sodium formaldehyde sulfoxylate is then rapidly
added to the alcohol solution of diamino diphenyl sulfone and the mixture
refluxed in the usual manner. It was found that the mixture should be refluxed
for a total of 5 hours and that a precipitate starts to form near the 3 hour
period. The reaction mixture is then cooled to 15°C and kept at this
temperature for about 1 hour. The precipitate formed in the filtrate is filtered
off rapidly and drained as much as possible to remove mother liquor and then
washed with small amounts of cold alcohol. The solid product is immediately
placed in a desiccator and dried over sulfuric acid for about 20 hours.
Therapeutic Function
Antibacterial (leprostatic)
Check Digit Verification of cas no
The CAS Registry Mumber 144-75-2 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 1,4 and 4 respectively; the second part has 2 digits, 7 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 144-75:
(5*1)+(4*4)+(3*4)+(2*7)+(1*5)=52
52 % 10 = 2
So 144-75-2 is a valid CAS Registry Number.
InChI:InChI=1/C14H16N2O6S3.2Na/c17-23(18)9-15-11-1-5-13(6-2-11)25(21,22)14-7-3-12(4-8-14)16-10-24(19)20;;/h1-8,15-16H,9-10H2,(H,17,18)(H,19,20);;/q;2*+1/p-2
