Technology Process of (1R)-1,2,3,4-tetrahydro-1-[(4-allyloxyphenyl)methyl]-6,7-bis(benzyloxy)isoquinoline
There total 6 articles about (1R)-1,2,3,4-tetrahydro-1-[(4-allyloxyphenyl)methyl]-6,7-bis(benzyloxy)isoquinoline which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
chloro {[(1S,2S)-(+)-2-amino-1,2-diphenylethyl]((4-toluenesulfonyl)amido)(p-cymene)}ruthenium(ll);
In
N,N-dimethyl-formamide;
at 0 - 20 ℃;
for 2h;
enantioselective reaction;
DOI:10.1002/ejoc.201300072
- Guidance literature:
-
Multi-step reaction with 5 steps
1: sodium hydroxide / methanol / 2 h / 35 °C
2: oxalyl dichloride / 2 h / 20 °C
3: sodium hydroxide / dichloromethane / 20 °C
4: trichlorophosphate / acetonitrile / 1 h / 90 °C
5: chloro {[(1S,2S)-(+)-2-amino-1,2-diphenylethyl]((4-toluenesulfonyl)amido)(p-cymene)}ruthenium(ll); / N,N-dimethyl-formamide / 2 h / 0 - 20 °C
With
oxalyl dichloride; chloro {[(1S,2S)-(+)-2-amino-1,2-diphenylethyl]((4-toluenesulfonyl)amido)(p-cymene)}ruthenium(ll); sodium hydroxide; trichlorophosphate;
In
methanol; dichloromethane; N,N-dimethyl-formamide; acetonitrile;
4: |Bischler-Napieralski Reaction;
DOI:10.1002/ejoc.201300072
- Guidance literature:
-
Multi-step reaction with 3 steps
1: sodium hydroxide / dichloromethane / 20 °C
2: trichlorophosphate / acetonitrile / 1 h / 90 °C
3: chloro {[(1S,2S)-(+)-2-amino-1,2-diphenylethyl]((4-toluenesulfonyl)amido)(p-cymene)}ruthenium(ll); / N,N-dimethyl-formamide / 2 h / 0 - 20 °C
With
chloro {[(1S,2S)-(+)-2-amino-1,2-diphenylethyl]((4-toluenesulfonyl)amido)(p-cymene)}ruthenium(ll); sodium hydroxide; trichlorophosphate;
In
dichloromethane; N,N-dimethyl-formamide; acetonitrile;
2: |Bischler-Napieralski Reaction;
DOI:10.1002/ejoc.201300072
