147189-43-3

Usage

Uses

Used in Pharmaceutical Industry:
Heptanedial, 4-nitrois used as a reactant in the synthesis of indoles, which are important in the pharmaceutical industry. These indoles are alkyl-substituted in the benzene ring, and they play a crucial role in the development of various drugs with diverse therapeutic applications, such as anti-inflammatory, anti-cancer, and anti-fungal agents.
Used in Chemical Synthesis:
In the field of chemical synthesis, Heptanedial, 4-nitroserves as a key intermediate for the production of various organic compounds. Its unique structure allows for further functionalization and modification, making it a valuable building block in the synthesis of complex molecules with potential applications in various industries, including pharmaceuticals, agrochemicals, and materials science.
Used in Research and Development:
Heptanedial, 4-nitrois also utilized in research and development for the exploration of new chemical reactions and the development of novel synthetic methods. Its reactivity and structural features make it an interesting candidate for studying reaction mechanisms and developing new strategies for the synthesis of complex organic molecules.

Upstream product

• 2985-49-1 diethyl 4-nitroheptanedioate 
• 75-52-5 nitromethane 
• 107-02-8 acrolein 

Downstream Products

• 900186-75-6 5-nitro-cyclohex-1-enecarbaldehyde 
• 1160562-12-8 (5-nitronona-1,8-diene-1,9-diyl)bis(phenyl sulfide) 
• 144024-32-8 4-<1-(4-methylphenyl)sulfonyl-3-pyrrolyl>-4-oxobutanal 
• 147189-48-8 3-<4-(methylphenyl)sulfonylaminomethylene>-1,1,7,7-tetramethoxy-4-heptanone 

Relevant academic research and scientific papers

Base-catalysed intramolecular hydroamination of vinyl sulfiies

Small amounts of n-butyllithium catalyse the highly efficient hydroamination of a large variety of vinyl sulfides. This novel methodology offers an easy access to a wide range of nitrogen heterocycles, including simple pyrrolidines and piperidines, as well as more complex bicyclic compounds. Subsequent transformations of the sulfur group led to the formation of functionalised alkaloid-like substructures. Wiley-VCH Verlag GmbH & Co. KGaA.

EXO- AND DIASTEREO- SELECTIVE SYNTHESES OF HIMBACINE ANALOGS

The application discloses a novel process for the preparation of himbacine analogs useful as thrombin receptor antagonists. The process is based in part on the use of a base-promoted dynamic epimerization of a chiral nitro center. The chemistry taught her

Preparation of alkyl-substituted indoles in the benzene portion. Part 8. Improved practical synthesis of 4,4-dialkoxy-1-(1-arylsulfonyl-3-pyrrolyl)-1-butanone and 4-(1-arylsulfonyl-3-pyrrolyl)-4-oxobutanal, and a novel synthetic procedure for 4-alkoxyindole derivatives

Important precursors (1 and 2) for the synthesis of 4-substituted indole derivatives were readily obtained by acid treatment of a tosylamide (13), which was prepared in a single operation by treatment of 10 with N-tosyl-N',N'-dimethylformamidine (TsN=CHNMe2). Compound (10) was effectively synthesized from nitromethane and acrolein by way of a nitro compound (15). A novel indole formation reaction from the tosyl-amide (13) to gain short access to 4-alkoxyindoles, such as 16, 17, 19, and 21 is presented.