1440337-92-7Relevant academic research and scientific papers
Description of a bivalent cannabinoid ligand with hypophagic properties
Fernandez-Fernandez, Cristina,Decara, Juan,Bermudez-Silva, Francisco J.,Sanchez, Eva,Morales, Paula,Gomez-Canas, Maria,Gomez-Ruiz, Maria,Callado, Luis F.,Goya, Pilar,Rodriguez De Fonseca, Fernando,Martin, M. Isabel,Fernandez-Ruiz, Javier,Meana, J. Javier,Jagerovic, Nadine
, p. 171 - 179 (2013)
A series of bivalent cannabinoid ligands is proposed. The synthesis of double amides based on the rimonabant structure separated by an alkyl chain and the evaluation of their affinities for cannabinoid receptors are reported. The data of 4d confirmed that a bivalent structure is a suitable scaffold for CB1 cannabinoid receptor binding. The compound 4d was selected for in vitro and in vivo pharmacological evaluations. Moreover, intraperitoneal administration of 4d to food-deprived rats resulted in a dose-dependent inhibition of feeding that was maintained up to 240 min. A series of bivalent cannabinoid ligands was synthesized. The data of 4d confirmed that a bivalent structure is a suitable scaffold for CB1 cannabinoid receptor binding. The compound 4d was selected for in vitro and in vivo pharmacological evaluations. Moreover, intraperitoneal administration of 4d to food-deprived rats resulted in a dose-dependent inhibition of feeding that was maintained up to 240 min.
