1440546-85-9

Upstream product

• 138490-94-5 2-iodoisovanillin 
• 1229403-09-1 3,4-dihydroxy-2-iodobenzaldehyde 
• 1440546-84-8 2-iodo-3,4-diisobutoxybenzaldehyde 
• 1440546-90-6 2-iodo-3,4-diisobutoxybenzoic acid 
• 74-88-4 methyl iodide 
• 621-59-0 isovanillin 
• 139-85-5 3,4-dihydroxybenzaldehyde 

Downstream Products

• 1440546-86-0 methyl 2-((2-amino-5-(benzyloxy)phenyl)ethynyl)-3,4-diisobutoxybenzoate 
• 1440546-87-1 tert-Butyl (2-(2-((2-amino-5-(benzyloxy)phenyl)ethynyl)-3,4-diisobutoxybenzamido) ethyl)carbamate 
• 1440546-88-2 ethyl2-((4-(benzyloxy)-2-((6-((2-((tert-butoxycarbonyl)amino)ethyl)carbamoyl)-2,3diisobutoxyphenyl)ethynyl)phenyl)amino)-2-oxoacetate 
• 1440546-81-5 2-((2-((6-((2-aminoethyl)carbamoyl)-2,3-diisobutoxyphenyl)ethynyl)-4-(benzyloxy)phenyl)amino)-2-oxoaceticacid 
• 1440546-91-7 2-((2-amino-5-(benzyloxy)phenyl)ethynyl)-3,4-diisobutoxybenzoic acid 
• 1440546-93-9 2-((4-(benzyloxy)-2-((6-((2-((tert-butoxycarbonyl)amino)ethyl)carbamoyl)-2,3-diisobutoxyphenyl)ethynyl)phenyl)amino)-2-oxoacetic acid 

Relevant academic research and scientific papers

AMPHIPATHIC AND OTHER DOUBLE-SIDED ALPHA-HELIX MIMETICS BASED ON A 1,2-DIPHENYLACETYLENE SCAFFOLD

Small-molecule scaffolds based on 1,2-diphenylacetylene that accurately replicate the spatial and angular projections of several side chains on both faces of an α-helix, specifically the i and i+7 side chains on one face, and the i and i+2 side chains on the other. The amphipathic α-helix mimetic can be used to disrupt disease-promoting protein-protein interactions that are mediated by α-helices.

Amphipathic α-helix mimetics based on a 1,2-diphenylacetylene scaffold

In order to mimic amphipathic α-helices, a novel scaffold based on a 1,2-diphenylacetylene was designed. NMR and computational modeling confirmed that an intramolecular hydrogen bond favors conformations of the 1,2-diphenylacetylene that allow for accurat