144062-62-4

Usage

Molecular structure

The molecule consists of a pyrrole ring (a five-membered ring with one nitrogen atom) and a methyl ester group (a methyl group attached to an oxygen atom) attached to a 4-methylphenyl group (a phenyl group with a methyl substituent at the 4-position).

Usage

Synthesis of pharmaceuticals, agrochemicals, and other organic compounds 1H-Pyrrole-2-carboxylic acid, 1-(4-methylphenyl)-, methyl ester is used as a building block or precursor in the synthesis of various pharmaceuticals, agrochemicals, and other organic compounds.

Potential applications

Medicinal chemistry, drug development, and industrial and research uses Due to its unique chemical properties and potential reactivity in various chemical reactions, 1H-Pyrrole-2-carboxylic acid, 1-(4-methylphenyl)-, methyl ester has potential applications in medicinal chemistry, particularly as a precursor in the development of new drugs, as well as other industrial and research uses.

Upstream product

• 22774-64-7 N-propargyl-4-methylaniline 
• 13887-54-2 methyl 2-methoxy-2-(piperidin-1-yl)acetate 
• 106-49-0 p-toluidine 
• 35524-50-6 1-(4-methylphenyl)-1H-pyrrole-2-carboxylic acid 
• 35524-48-2 1-(4-methylphenyl)pyrrole-2-carbonitrile 
• 30186-38-0 1-(4-methylphenyl)-2-formyl-1H-pyrrole 
• 827-60-1 1-(4-methylphenyl)-1H-pyrrole 

Downstream Products

• 144062-63-5 methyl 1-<4-(bromomethyl)phenyl>-1H-pyrrole-2-carboxylate 

Relevant academic research and scientific papers

Copper(II)-Catalyzed [4+1] annulation of propargylamines with N,O-acetals: Entry to the synthesis of polysubstituted pyrrole derivatives

Described herein is the CuCl2-catalyzed [4+1] annulation of a variety of propargylamines with N,O-acetals that function as a C1 unit, leading to the production of polysubstituted pyrrole derivatives. Three important features of the N,O-acetal during the [4+1] annulation series via 5-endo-dig cyclization are described: an enolizable substituent adjacent to the central sp3-carbon is required, the central sp3-carbon displays the functions of both an electrophile and a nucleophile, and liberation of the secondary amine smoothly leads to the aromatization. A CuCl2-catalyzed [4+1] annulation of propargylamines with N,O-acetals having an ester, a ketone, and an amide moiety, leading to the facile preparation of polysubstituted pyrrole derivatives is presented. This annulation series was achieved through 5-endo-dig cyclization and subsequent aromatization in one pot.

Nonpeptide angiotensin II antagonists: N-phenyl-1H-pyrrole derivatives are angiotensin II receptor antagonists

A series of 5-[1-[4-[(4,5-disubstituted-1H-imidazol-1-yl)methyl]- substituted]-1H-pyrrol-2-yl]-1H-tetrazoles and 5-[1-[4-[(3,5-dibutyl-1H- 1,2,4-triazol-1-yl)methyl]-substituted]-1H-pyrrol-2-yl]-1H-tetrazoles were investigated as novel AT1-sele

N-SUBSTITUTED (ALPHA-IMIDAZOLYL-TOLUYL) PYRROLE COMPOUNDS FOR TREATMENT OF CIRCULATORY DISORDERS

A class of N-substituted (α-imidazolyl-toluyl)pyrrole compounds described for use in treatment of circulatory disorders. Compounds of particular interest are angiotensin II antagonists of the formula STR1 wherein m is one; wherein each of R 0 and R 1 is i

N-SUBSTITUTED N-(ALPHA-TRIAZOLYL-TOLUYL)PYRROLE COMPOUNDS AND USE FOR TREATMENT OF CIRCULATORY DISORDERS

A class of N-substituted N-(α-triazolyltoluyl)pyrrole compounds described for use in treatment of circulatory disorders. Compounds of particular interest are angiotensin II antagonists of the formula STR1 wherein m is one; wherein R 1 is selected from methyl, ethyl, n-propyl, isopropyl, n-butyl, sec-butyl, isobutyl, tert-butyl, 4-methylbutyl, n-pentyl, neopentyl, phenyl, benzyl, phenethyl, cyclohexyl, cyclohexylmethyl, cyclohexylethyl, cyclohexanoyl, 1-oxo-2-cyclohexylethyl, benzoyl, 1-oxo-2-phenethyl, 1-oxopropyl, 1-oxobutyl, 1-oxopentyl and 2-hydroxybutyl; wherein R 2 is selected from methyl, ethyl, n-propyl, isopropyl, n-butyl, sec-butyl, isobutyl, tert-butyl, n-pentyl, isopentyl, neopentyl, phenyl, benzyl, phenethyl, cyclohexyl, cyclohexylmethyl, propylthio, butylthio, and hydroxyalkyl; wherein each of R 3, R 4, R 5, R 6, R 7, R 8, R 9 and R. sup.10 is independently selected from hydrido, halo, nitro, trifluoromethyl, hydroxy, alkoxy, cyano, carboxyl and methoxycarbonyl; with the proviso that at least one of R 5 and R 8 must be selected from COOH, SH, PO 3 H 2, SO 3 H, CONHNH 2, CONHNHSO 2 CF 3, OH, STR2 wherein each of R 42 and R 43 is independently selected from chloro, cyano, nitro, trifluoromethyl, methoxycarbonyl and trifluoromethylsulfonyl; or a tautomer thereof or a pharmaceutically-acceptable salt thereof. These compounds are particularly useful in treatment or control of hypertension and congestive heart failure.