1440753-63-8 Usage
Molecular Structure
The compound has a complex molecular structure that includes a piperidine ring, a benzimidazole ring, and various substituents such as a phenyl group, a carbonyl group, and an ester group.
Thienodiazepine Class
Etizolam belongs to the thienodiazepine class of drugs, which are known for their sedative and anxiolytic effects.
Synthetic Compound
It is a synthetic chemical compound, meaning it is not naturally occurring and is created through chemical reactions.
Sedative and Anxiolytic Effects
Etizolam is commonly used for its sedative (calming) and anxiolytic (anti-anxiety) effects, making it a popular candidate for the treatment of anxiety and insomnia.
Controlled Substance
Due to its potential for side effects and substance abuse, etizolam is classified as a controlled substance in several countries.
Medical Supervision
It is important to use this chemical under the guidance and supervision of a qualified medical professional to minimize the risk of adverse effects and dependency.
Ester Functional Group
The compound contains an ester functional group (-COO-), which is typically associated with fruity smells and flavors.
Dimethylamino Group
The presence of a dimethylamino group (-N(CH3)2) contributes to the basic nature of the compound and may be related to its pharmacological effects.
Phenyl Group
The phenyl group (a six-carbon ring with delocalized electrons) is a common structural motif in many drugs and can influence the compound's solubility, stability, and pharmacokinetics.
Methoxycarbonyl Group
The methoxycarbonyl group (-OCOOCH3) is an ester derivative of a carboxylic acid, which can affect the compound's reactivity and solubility.
2-Oxo
The "2-oxo" part of the name indicates the presence of a carbonyl group (C=O) at the second position of the molecule, which can be important for the compound's biological activity.
1-(2-Phenyl-1H-benzimidazol-1-yl)ethyl
This part of the name refers to the presence of a 2-phenyl-1H-benzimidazole group attached to an ethyl side chain, which is a key structural component of the compound and may contribute to its pharmacological properties.
Check Digit Verification of cas no
The CAS Registry Mumber 1440753-63-8 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,4,4,0,7,5 and 3 respectively; the second part has 2 digits, 6 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 1440753-63:
(9*1)+(8*4)+(7*4)+(6*0)+(5*7)+(4*5)+(3*3)+(2*6)+(1*3)=148
148 % 10 = 8
So 1440753-63-8 is a valid CAS Registry Number.
1440753-63-8Relevant articles and documents
Structure guided design and kinetic analysis of highly potent benzimidazole inhibitors targeting the PDEδ prenyl binding site
Zimmermann, Gunther,Schultz-Fademrecht, Carsten,Küchler, Philipp,Murarka, Sandip,Ismail, Shehab,Triola, Gemma,Nussbaumer, Peter,Wittinghofer, Alfred,Waldmann, Herbert
, p. 5435 - 5448 (2014/07/08)
K-Ras is one of the most frequently mutated signal transducing human oncogenes. Ras signaling activity requires correct cellular localization of the GTPase. The spatial organization of K-Ras is controlled by the prenyl binding protein PDEδ, which enhances Ras diffusion in the cytosol. Inhibition of the Ras-PDEδ interaction by small molecules impairs Ras localization and signaling. Here we describe in detail the identification and structure guided development of Ras-PDEδ inhibitors targeting the farnesyl binding pocket of PDEδ with nanomolar affinity. We report kinetic data that characterize the binding of the most potent small molecule ligands to PDEδ and prove their binding to endogenous PDEδ in cell lysates. The PDEδ inhibitors provide promising starting points for the establishment of new drug discovery programs aimed at cancers harboring oncogenic K-Ras.
