1440753-74-1

Basic information

• Product Name: 1-Piperidinecarboxylic acid, 4-[2-hydroxy-1-(2-phenyl-1H-benziMidazol-1-yl)ethyl]-, 1,1-diMethylethyl ester
• Synonyms: 1-Piperidinecarboxylic acid, 4-[2-hydroxy-1-(2-phenyl-1H-benziMidazol-1-yl)ethyl]-, 1,1-diMethylethyl ester;tert-Butyl 4-(2-hydroxy-1-(2-phenyl-1H-benzo[d]imidazol-1-yl)ethyl)piperidine-1-carboxylate
• CAS NO: 1440753-74-1
• Molecular Formula: C₂₅H₃₁N₃O₃
• Molecular Weight: 421.53194
• Mol File: 1440753-74-1.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1-Piperidinecarboxylic acid, 4-[2-hydroxy-1-(2-phenyl-1H-benziMidazol-1-yl)ethyl]-, 1,1-diMethylethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Piperidinecarboxylic acid, 4-[2-hydroxy-1-(2-phenyl-1H-benziMidazol-1-yl)ethyl]-, 1,1-diMethylethyl ester(1440753-74-1)
• EPA Substance Registry System: 1-Piperidinecarboxylic acid, 4-[2-hydroxy-1-(2-phenyl-1H-benziMidazol-1-yl)ethyl]-, 1,1-diMethylethyl ester(1440753-74-1)

Safety Data

• Hazardous Substances Data: 1440753-74-1(Hazardous Substances Data)

Usage

Chemical Class

N-acyl-alpha amino acids and derivatives
This compound belongs to a class of organic compounds that have an amide group attached to an alpha amino acid.

Derivative of Piperidinecarboxylic Acid

The compound is derived from piperidinecarboxylic acid, which is a cyclic amine with a carboxylic acid group.

1,1-Dimethylethyl Ester Group

The compound has a 1,1-dimethylethyl ester group attached to it, which is an ester formed by the reaction of a carboxylic acid with an alcohol.

4-[2-Hydroxy-1-(2-phenyl-1H-benziMidazol-1-yl)ethyl] Moiety

This part of the compound contains a 2-phenyl-1H-benzimidazole group attached to a hydroxyethyl group, which is connected to the piperidine ring.

Structural Similarity to Benzodiazepines

The compound has a similar structure to benzodiazepines, a class of drugs known for their sedative and anxiolytic effects.

Potential Pharmaceutical Applications

Due to its structural similarity to benzodiazepines, the compound may have potential pharmaceutical applications. However, further research is needed to fully understand its properties and potential uses.

Upstream product

• 137076-22-3 tert butyl 4-formylpiperidine-1-carboxylate 
• 65-85-0 benzoic acid 
• 146651-75-4 tert–butyl (2–aminophenyl)carbamate 
• 716-79-0 2-phenyl-1H-benzoimidazole 
• 24424-99-5 di-tert-butyl dicarbonate 
• 1440753-53-6 N-benzyl-2-(2-phenyl-1H-benzo[d]imidazol-1-yl)-2-(piperidin-4-yl)acetamide 
• 1440753-63-8 tert-butyl 4-(2-(benzyl(tert-butoxycarbonyl)amino)-2-oxo-1-(2-phenyl-1H-benzo[d]imidazol-1-yl)ethyl)piperidine-1-carboxylate 

Downstream Products

• 1565835-93-9 tert-butyl 4-(2-(1-(1-(2-chloro-6-fluorobenzyl)-1H-benzo[d]imidazol-2-yl)piperidine-4-carbonyloxy)-1-(2-phenyl-1H-benzo[d]imidazol-1-yl)ethyl)piperidine-1-carboxylate 
• 1613404-72-0 N-(2-(2-phenyl-1H-benzo[d]imidazol-1-yl)-2-(piperidin-4-yl)ethyl)-1-(1-(thiophen-3-ylmethyl)-1H-benzo[d]imidazol-2-yl)piperidine-4-carboxamide trifluoroacetate 
• 1440754-07-3 tert-butyl-4-(2-(4-(1-benzyl-1H-benzo[d]imidazol-2-yl)phenoxy)-1-(2-phenyl-1H-benzo[d]imidazol-1-yl)ethyl)piperidine-1-carboxylate 
• 1565835-80-4 tert-butyl 4-(2-(4-(1-(3-methylbenzyl)-1H-benzo[d]imidazol-2-yl)phenoxy)-1-(2-phenyl-1H-benzo[d]imidazol-1-yl)ethyl)piperidine-1-carboxylate 
• 1565836-09-0 1-(3-methylbenzyl)-2-(4-(2-(2-phenyl-1H-benzo[d]imidazol-1-yl)-2-(piperidin-4-yl)ethoxy)phenyl)-1H-benzo[d]imidazole 
• 1565835-81-5 tert-butyl 4-(2-(4-(1-(4-fluorobenzyl)-1H-benzo[d]imidazol-2-yl)phenoxy)-1-(2-phenyl-1H-benzo[d]imidazol-1-yl)ethyl)piperidine-1-carboxylate 
• 1565836-10-3 1-(4-fluorobenzyl)-2-(4-(2-(2-phenyl-1H-benzo[d]imidazol-1-yl)-2-(piperidin-4-yl)ethoxy)phenyl)-1H-benzo[d]imidazole 
• 1565835-82-6 tert-butyl 4-(1-(2-phenyl-1H-benzo[d]imidazol-1-yl)-2-(4-(1-(pyridin-2-ylmethyl)-1H-benzo[d]imidazol-2-yl)phenoxy)ethyl)-piperidine-1-carboxylate 
• 1565835-79-1 tert-butyl 4-(2-(4-(1-(2-methylbenzyl)-1H-benzo[d]imidazol-2-yl)phenoxy)-1-(2-phenyl-1H-benzo[d]imidazol-1-yl)ethyl)piperidine-1-carboxylate 
• 1565835-96-2 tert-butyl 4-(2-(1,3-dioxoisoindolin-2-yl)-1-(2-phenyl-1H-benzo[d]imidazol-1-yl)ethyl)piperidine-1-carboxylate 

Relevant articles and documents

BENZIMIDAZOLES FOR THE TREATMENT OF CANCER

The present invention relates to novel substituted benzimidazoles and stereoisomeric forms, prodrugs, solvates, hydrates and/or pharmaceutically acceptable salts of these compounds as well as pharmaceutical compositions containing at least one of these substituted benzimidazoles together with pharmaceutically acceptable carrier, excipient and/or diluents. Said novel substituted benzimidazoles binding to the prenyl binding pocket of PDEδ have been identified as useful for the prophylaxis and treatment of cancer by the inhibition of the binding of PDEδ to K-Ras and of oncogenic Ras signalling in cells by altering its localization leading to cell death or inhibition of proliferation.

Benzimidazoles for the treatment of cancer

The present invention relates to novel substituted benzimidazoles and stereoisomeric forms, prodrugs, solvates, hydrates and/or pharmaceutically acceptable salts of these compounds as well as pharmaceutical compositions containing at least one of these substituted benzimidazoles together with pharmaceutically acceptable carrier, excipient and/or diluents. Said novel substituted benzimidazoles binding to the prenyl binding pocket of PDEδ have been identified as useful for the prophylaxis and treatment of cancer by the inhibition of the binding of PDEδ to K-Ras and of oncogenic Ras signalling in cells by altering its localization leading to cell death or inhibition of proliferation.